PMID: 9547866Apr 21, 1998Paper

Systemic histopathology of rats treated with 6-sulfanilamidoindazole, a novel arthritogenic sulfonamide

Toxicologic Pathology
Y OhmachiK Doi

Abstract

6-Sulfanilamidoindazole (6SAI) is a sulfonamide that induces acute, self-limiting arthritis in rats, and 6SAI-induced arthritis is thought to be a model for testing anti-inflammatory agents. In this study, in order to clarify the location of arthritis and relationships between arthritis and other changes in this model, we have investigated the detailed pathologic changes in rats administered orally with 6SAI (125, 250, 500 mg/kg) daily for 4 wk in a time-course experiment. Moderate to severe arthritis was observed in rats of middle- and high-dose groups. Histologically, in the affected ankle, exudative synovitis and periarthritis were observed at 1 wk, granulation tissue formation with angiogenesis and periosteal new bone formation at 2 wk, and marked fibrosis of affected area at 4 wk, respectively. In addition to these changes, in periarticular and periosteal tissues of affected ankles, subendothelial insudation of small-sized arteries and medial fibrinoid degeneration of medium-sized arteries were observed at 1 and 2 wk and intimal thickening and medial hypertrophy at 4 wk, respectively. No arterial changes were observed in the unaffected ankles. Similar arterial changes were often observed in the liver, thyroid glands, and l...Continue Reading

References

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Citations

Aug 14, 2012·Biosensors & Bioelectronics·So-Young WonYoon-Bo Shim
Apr 3, 2002·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Yasushi OhmachiKunio Doi
Apr 29, 2014·Toxicologic Pathology·Kaïdre BendjamaPatrice Cacoub

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