Systemic hypertension associated retinal microvascular changes can be detected with optical coherence tomography angiography.

Scientific Reports
Christopher SunAnna Cs Tan

Abstract

A major complication of hypertension is microvascular damage and capillary rarefaction is a known complication of hypertensive end-organ damage which confers a higher risk of systemic disease such as stroke and cardiovascular events. Our aim was to study the effect of hypertension on the retinal microvasculature using non-invasive optical coherence tomography angiography (OCTA). We performed a case-control study of 94 eyes of 94 participants with systemic hypertension and 46 normal control eyes from the Singapore Chinese Eye Study using a standardized protocol to collect data on past medical history of hypertension, including the number and type of hypertensive medications and assessed mean arterial pressure. Retinal vascular parameters were measured in all eyes using OCTA. In the multivariate analysis adjusting for confounders, compared to controls, eyes of hypertensive patients showed a decrease in the macular vessel density at the level of the superficial [OR 0.02; 95% CI, 0 to 0.64; P 0.027] and deep venous plexuses [OR 0.03; 95% CI, 0 to 0.41; P 0.009] and an increase in the deep foveal avascular zone. This shows that hypertension is associated with reduced retinal vessel density and an increased foveal avascular zone, esp...Continue Reading

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Citations

Feb 23, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Martin Dominik LeclaireMaged Alnawaiseh
Feb 27, 2021·Scientific Reports·Jacqueline ChuaLeopold Schmetterer
Apr 22, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Maged AlnawaisehNicole Eter
May 4, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Eyüp DüzgünAkın Çakır
Oct 16, 2021·American Journal of Ophthalmology·Yun HsiaChien-Chia Su

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Software Mentioned

AngioVue
R Core Team
R3
OCTA
AngioVue AngioAnalytics
ImageJ

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