Systemic immune-inflammation index in germ-cell tumours

British Journal of Cancer
Michal ChovanecJozef Mardiak

Abstract

We evaluated systemic immune-inflammation index (SII) and its association with patient outcome in germ-cell tumours (GCTs). Two independent cohorts of patients were analysed; the discovery set (n=171) from a single institution and the validation set (n=181) previously included in a study evaluating PD-L1 in GCTs. The SII was calculated using platelet (P), neutrophil (N) and lymphocyte (L) counts before chemotherapy and correlated with survival using regression analyses and Kaplan-Meier method. In the discovery cohort, the SII was associated with poor risk clinical features. Patients with low SII had significantly longer progression-free survival (HR=0.22, 95% CI 0.12-0.41, P<0.001) and overall survival (OS) (HR=0.16, 95% CI 0.08-0.32, P<0.001) compared to high SII. This index was independent of International Germ Cell Cancer Collaborative Group criteria in multivariable Cox regression analysis for OS and was validated in an independent cohort. When combining PD-L1 expression on tumour infiltrating lymphocytes (TILs) and SII, we identified three distinctive prognostic groups. High SII was associated with poor outcome in GCTs. Combination of PD-L1 positive TILs and SII could further refine prognosis in GCTs.

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Citations

Nov 1, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Jun LuPing Li
Oct 28, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Chenwei WangYunfei Yuan
Oct 24, 2019·Journal of Oncology·Giuseppe SchepisiUgo De Giorgi
Jan 20, 2019·Journal of Translational Medicine·Ke ZhangHao Chen
Mar 13, 2019·Frontiers in Endocrinology·Giuseppe SchepisiUgo De Giorgi
Oct 20, 2019·Cancers·Ugo De GiorgiGiorgia Mangili
Sep 15, 2020·Frontiers in Oncology·Maria Concetta CursanoUgo De Giorgi
Oct 20, 2020·Frontiers in Oncology·Katarina KalavskaMichal Mego
Nov 4, 2020·Expert Review of Anticancer Therapy·Kristyna KozakovaMichal Chovanec
Oct 13, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yangpei PengJun Ma
Feb 25, 2021·Current Oncology·Domen RibnikarJeremy Lewin
Mar 28, 2020·Current Drug Targets·Kerstin JunkerRodolfo Montironi

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Methods Mentioned

BETA
biopsy

Software Mentioned

NCSS

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