Systemic immune-inflammation index predicting chemoradiation resistance and poor outcome in patients with stage III non-small cell lung cancer

Journal of Translational Medicine
Yu-Suo TongYing-Jian Song

Abstract

There is increasing evidence that the existence of systemic inflammation response is correlated with poor prognosis in several solid tumors. The aim of this retrospective study was to investigate the association between systemic immune-inflammation index (SII) and therapy response and overall survival in patients with stage III non-small cell lung cancer (NSCLC). The prognostic values of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and prognostic nutritional index (PNI) were also evaluated. In total, 332 patients with new diagnosis of stage III NSCLC were included in this retrospective analysis. SII was defined as platelet counts × neutrophil counts/lymphocyte counts. Receiver operating characteristic (ROC) curve was used to evaluate the optimal cut-off value for SII, NLR, PLR and PNI. Univariate and multivariate survival analysis were performed to identify the factors correlated with overall survival. Applying cut-offs of ≥ 660 (SII), ≥ 3.57 (NLR), ≥ 147 (PLR), ≤ 52.95 (PNI), SII ≥ 660 was significantly correlated with worse ECOG PS (< 0.001), higher T stage (< 0.001), advanced clinical stage (p = 0.019), and lower response rate (p = 0.018). In univariate analysis, SII ≥ 660, NLR ≥ 3.57, PLR ≥ 147,...Continue Reading

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Citations

Mar 13, 2018·Japanese Journal of Clinical Oncology·Isamu WatanabeHikaru Watanabe
Mar 30, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Gerd JomrichMartin Schindl
May 26, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·V Palomar-AbrilI C M Maiques
Jan 20, 2019·Journal of Translational Medicine·Ke ZhangHao Chen
Mar 25, 2019·Oncoimmunology·Pranav MurthyMichael T Lotze
Apr 7, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Sebnem Yucel, Burak Bilgin
Feb 6, 2021·Journal of Gastrointestinal Cancer·Giulia RovestiAndrea Casadei-Gardini
Jan 21, 2021·Clinical Interventions in Aging·Jie WangXiaokun Li
Mar 5, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yiyi XieXiuzhi Duan
Apr 23, 2021·International Journal of Clinical Practice·Ethem AcarKemal Gökçek
Jun 19, 2021·Surgery Today·Fumihiro TerasakiKatsuhiko Uesaka

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Methods Mentioned

BETA
biopsy
dissection
surgical resection

Software Mentioned

SPSS

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