Systemic immunomodulatory treatments for atopic dermatitis: protocol for a systematic review with network meta-analysis

BMJ Open
Aaron Mark DruckerCarsten Flohr

Abstract

There are numerous new systemic treatments for atopic dermatitis in various stages of development and most are being compared with placebo rather than active comparators. In order to understand the relative efficacy and safety of existing and new treatments for atopic dermatitis, robust mixed comparisons (ie, direct and indirect) would be beneficial. To address this gap, this protocol describes methods for a systematic review and network meta-analysis of systemic treatments for atopic dermatitis. We will update the search of a previous systematic review, including searches of the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, Latin American and Caribbean Health Science Information database and the Global Resource of EczemA Trials database in addition to clinical trial protocol registries. Title, abstract and full paper screening as well as data extraction will be conducted in duplicate by independent researchers. Primary outcomes include efficacy with regards to clinician-reported signs and patient-reported symptoms and safety with regards to withdrawal from treatment due to adverse events and the occurrence of serious adverse events. Secondary outcomes will include change in quality of life and itch severity....Continue Reading

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Citations

Aug 3, 2019·The Australasian Journal of Dermatology·Saxon SmithPeter Foley
Jul 14, 2020·The British Journal of Dermatology·A M Drucker
Aug 3, 2020·Current Opinion in Allergy and Clinical Immunology·Nir ErdinestAbraham Solomon
Mar 19, 2021·Dermatology : International Journal for Clinical and Investigative Dermatology·Shuying ZhouBinghua Zhu

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Software Mentioned

gemtc R package
Cochrane Risk of Bias
HOME
Ovid

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.