Abstract
To describe the systemic immunosuppression protocol used at the Cincinnati Eye Institute and University of Cincinnati, and to evaluate the success, tolerability, and side effects of systemic immunosuppression in patients undergoing ocular surface stem cell transplantation (OSST). Retrospective study of all patients who had OSST from 1997 to 2007 and received follow-up for systemic immunosuppression at the Cincinnati Eye Institute. Patients were analyzed for demographics, systemic immunosuppression exposure, ocular surface stability, efficacy, and toxicity variables. A total of 225 eyes from 136 patients with a mean age of 43.6 years (range, 8.9-80.6 years) underwent OSST with systemic immunosuppression. The most common systemic immunosuppression regimen consisted of tacrolimus, mycophenolate mofetil, and a short course (1-3 months) of prednisone (102/136 patients, 75%). Prophylactic valganciclovir and trimethoprim/sulfamethoxazole (dapsone if sulfa allergy was present) were also used. Mean duration of immunosuppression was 42.1 months (range, 3.6-128 months) and mean follow-up time after OSST was 53.9 months (range, 3.6-147.3 months). At the patients' final follow-up visit, 105/136 patients (77.2%) had a stable ocular surface. ...Continue Reading
References
Dec 15, 1984·American Journal of Ophthalmology·P A TreselerF Sanfilippo
Jan 1, 1981·American Journal of Ophthalmology·J D Salisbury, B M Gebhardt
Jan 1, 1995·Eye·J Y Niederkorn
Jan 12, 2000·Current Opinion in Nephrology and Hypertension·Y F Vanrenterghem
Sep 29, 2000·Cornea·E J Holland, G S Schwartz
Oct 3, 2001·Ophthalmology·C M SloperH S Dua
Jun 5, 2002·Ophthalmology·Abraham SolomonScheffer C G Tseng
Jul 3, 2002·Ophthalmology·Luca Ilari, Sheraz M Daya
Aug 15, 2002·Transplantation Proceedings·E S Woodle
Apr 10, 2003·Ophthalmology Clinics of North America·Joung Y KimEdward J Holland
Dec 11, 2003·Drugs·Therese M Chapman, Gillian M Keating
Jun 29, 2004·Cornea·Edward J Holland, Gary S Schwartz
Apr 26, 2005·Transplantation Proceedings·R R AllowayE S Woodle
Jul 20, 2007·International Ophthalmology·Khalid F Tabbara
Dec 21, 2007·The New England Journal of Medicine·Henrik EkbergUNKNOWN ELITE-Symphony Study
May 6, 2008·American Journal of Ophthalmology·Stephen C TeohRichard W J Lee
Nov 11, 2009·Archives of Ophthalmology·Lingyi LiangScheffer C G Tseng
Jan 1, 2010·American Journal of Ophthalmology·Ebenezer DanielJohn H Kempen
Feb 19, 2010·Ophthalmology·Ammar MiriHarminder S Dua
Citations
Dec 12, 2012·American Journal of Ophthalmology·Clara C Chan, Edward J Holland
Aug 25, 2015·American Journal of Ophthalmology·Carl ShenEdward J Holland
Jul 24, 2015·Cornea·Edward J Holland
Jun 27, 2015·BMJ Case Reports·Victoria SquissatoClara C Chan
Feb 3, 2015·Cornea·Asadolah MovahedanEdward J Holland
Aug 3, 2016·The Ocular Surface·Jennifer RossenAli Djalilian
Oct 16, 2016·Journal français d'ophtalmologie·V KocabaC Burillon
Jul 29, 2016·Cornea·Medi EslaniAli R Djalilian
Apr 6, 2017·Current Opinion in Ophthalmology·Albert Y Cheung, Edward J Holland
Jun 15, 2017·Cornea·Albert Y CheungEdward J Holland
Jun 19, 2018·Cornea·Albert Y CheungEdward J Holland
Jul 14, 2018·Cornea·Albert Y CheungEdward J Holland
Oct 30, 2018·Cornea·Albert Y CheungEdward J Holland
Sep 6, 2019·Stem Cells Translational Medicine·Vincent M BorderieHélène Rouard
Sep 19, 2017·Cornea·Yoshinori Oie, Kohji Nishida
Jun 24, 2017·Cornea·Lorena SepsakosEdward J Holland
Nov 4, 2017·Cornea·Albert Y CheungEdward J Holland
Apr 9, 2020·Cornea·Albert Y CheungEdward J Holland
Nov 28, 2017·Seminars in Ophthalmology·Jia Yin, Ula Jurkunas
Dec 6, 2019·Stem Cells Translational Medicine·Catherine J JacksonTor P Utheim
Jul 28, 2018·Journal of Ophthalmology·Ying DongRobert M Lavker
Jan 5, 2020·Stem Cell Research & Therapy·Francisco BandeiraJodhbir S Mehta
Jun 6, 2020·Cornea·Albert Y CheungEdward J Holland
Dec 17, 2020·Asia-Pacific Journal of Ophthalmology·Geetha IyerHiren Matai
Mar 24, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jyoti SharmaNirbhai Singh
Jul 21, 2020·American Journal of Ophthalmology·Ghasem YazdanpanahAli R Djalilian
Jun 8, 2021·Frontiers in Medicine·Matias SoiferVictor L Perez
Jul 6, 2021·Frontiers in Medicine·Tais Hitomi WakamatsuJosé Álvaro Pereira Gomes
Oct 4, 2020·Cornea·Joseph H JeffreyEdward J Holland
Dec 31, 2017·Survey of Ophthalmology·Wei ZhongDimitri T Azar