Systemic inflammation affects reperfusion following transient cerebral ischaemia

Experimental Neurology
Fiona E BurrowsIngo Schiessl

Abstract

Reperfusion after stroke is critical for improved patient survival and recovery and can be achieved clinically through pharmacological (recombinant tissue plasminogen activator) or physical (endovascular intervention) means. Yet these approaches remain confined to a small percentage of stroke patients, often with incomplete reperfusion, and therefore there is an urgent need to learn more about the mechanisms underlying the no-reflow phenomenon that prevents restoration of adequate microvascular perfusion. Recent evidence suggests systemic inflammation as an important contributor to no-reflow and to further investigate this here we inject interleukin 1 (IL-1) i.p. 30 min prior to an ischaemic challenge using a remote filament to occlude the middle cerebral artery (MCA) in mice. Before, during and after the injection of IL-1 and occlusion we use two-dimensional optical imaging spectroscopy to record the spatial and temporal dynamics of oxyhaemoglobin concentration in the cortical areas supplied by the MCA. Our results reveal that systemic inflammation significantly reduces oxyhaemoglobin reperfusion as early as 3h after filament removal compared to vehicle injected animals. CD41 immunohistochemistry shows a significant increase o...Continue Reading

References

Mar 1, 1995·Stroke; a Journal of Cerebral Circulation·A J GrauH Becher
Jul 22, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Q L Lu, T A Partridge
Oct 26, 1999·Journal of Cardiovascular Risk·M Bøttcher, E Falk
Oct 7, 2000·Stroke; a Journal of Cerebral Circulation·N VilaA Chamorro
Mar 12, 2003·Cell·Thorsten CramerRandall S Johnson
Aug 18, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jeremy K BrownHugh R P Miller
Dec 17, 2004·The New England Journal of Medicine·Liam SmeethPatrick Vallance
Jan 5, 2005·Seminars in Vascular Medicine·Antonio PintoGiuseppe Licata
Sep 20, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·H C A EmsleyUNKNOWN Acute Stroke Investigators
Dec 2, 2005·Current Opinion in Hematology·Vahid Afshar-Kharghan, Perumal Thiagarajan
Oct 25, 2007·Biochemical Society Transactions·B W McCollN J Rothwell
Dec 19, 2007·Circulation·Wayne RosamondUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 19, 2007·Neurocritical Care·Hedley C A EmsleyStephen J Hopkins
Mar 1, 2008·Neuropharmacology·Kristian P DoyleMary P Stenzel-Poore
Sep 16, 2008·Neuroscience·B W McCollN J Rothwell
Sep 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Barry W McCollStuart M Allan
Oct 15, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Barry W McCollCatherine B Lawrence
Mar 5, 2010·Blood·Peter ThorntonNancy J Rothwell
Jul 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adám DénesNancy Rothwell
Jan 21, 2011·Journal of Visualized Experiments : JoVE·Odilo EngelVincent Prinz
Mar 29, 2011·Journal of the Neurological Sciences·Burhan TurgutMuzaffer Demir
Jun 5, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charlotte AllenStuart M Allan
Jun 21, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Sandeep AnkolekarPhilip M W Bath
Oct 3, 2012·Molecular and Cellular Neurosciences·Katie N MurrayStuart M Allan
Nov 20, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fiona E BurrowsIngo Schiessl
Feb 24, 2015·Frontiers in Cellular Neuroscience·Katie N MurrayStuart M Allan
Aug 5, 2015·Journal of Neuroinflammation·Samaneh MaysamiCatherine B Lawrence
Sep 5, 2015·Stroke; a Journal of Cerebral Circulation·Josephine HerzThorsten R Doeppner

❮ Previous
Next ❯

Citations

Jul 28, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Runze Yang, Jeff F Dunn
Oct 20, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gina HadleyAlastair M Buchan
Mar 15, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nguyen MaiMarc W Halterman
Feb 16, 2018·Nature Reviews. Disease Primers·Wiesje M van der FlierPhilip Scheltens
Jun 30, 2019·Journal of Neuroscience Research·Jia LiXiangyan Chen
Dec 23, 2020·Brain : a Journal of Neurology·Sebok K Halder, Richard Milner
May 12, 2021·Experimental Neurobiology·Qian JiangYuchuan Ding

❮ Previous
Next ❯

Software Mentioned

ARRIVE

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier & Cytokines

Some cytokines are able to cross the blood brain barrier through transport systems and enter the cerebrospinal fluid and interstitial fluid spaces. Here is the latest research on cytokines crossing the blood brain barrier and how this can affect tissues within the CNS.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Fiona E BurrowsIngo Schiessl
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Adam DenesStuart M Allan
© 2022 Meta ULC. All rights reserved