Systemic inflammation and higher perception of dyspnea mimicking asthma in obese subjects

The Journal of Allergy and Clinical Immunology
Carlos CarpioFrancisco García-Río

Abstract

There are a variable number of obese subjects with self-reported diagnosis of asthma but without current or previous evidence of airflow limitation, bronchial reversibility, or airway hyperresponsiveness (misdiagnosed asthma). However, the mechanisms of asthma-like symptoms in obesity remain unclear. We sought to evaluate the perception of dyspnea during bronchial challenge and exercise testing in obese patients with asthma and misdiagnosed asthma compared with obese control subjects to identify the mechanisms of asthma-like symptoms in obesity. In a cross-sectional study we included obese subjects with asthma (n = 25), misdiagnosed asthma (n = 23), and no asthma or respiratory symptoms (n = 27). Spirometry, lung volumes, exhaled nitric oxide levels, and systemic biomarker levels were measured. Dyspnea scores during adenosine bronchial challenge and incremental exercise testing were obtained. During bronchial challenge, patients with asthma or misdiagnosed asthma reached a higher Borg-FEV1 slope than control subjects. Moreover, maximum dyspnea and the Borg-oxygen uptake (V'O2) slope were significantly greater during exercise in subjects with asthma or misdiagnosed asthma than in control subjects. The maximum dyspnea achieved du...Continue Reading

References

Jul 1, 1991·The American Review of Respiratory Disease·D A MahlerG T O'Connor
Jan 1, 1982·Medicine and Science in Sports and Exercise·G A Borg
Nov 1, 1994·Brain Research. Molecular Brain Research·K YabuuchiM Satoh
Nov 26, 1999·Archives of Internal Medicine·C A CamargoF E Speizer
Mar 24, 2000·BMJ : British Medical Journal·B Stenius-AarnialaP Mustajoki
Jul 2, 2002·Archives of Internal Medicine·Don D SinS F Paul Man
Jan 14, 2003·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN American College of Chest Physicians
Mar 26, 2003·Anesthesia and Analgesia·Raf F De JonghRené J Heylen
May 10, 2003·American Journal of Respiratory and Critical Care Medicine·Robert M Ross
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·T M CunhaS H Ferreira
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
May 4, 2005·The Journal of Allergy and Clinical Immunology·Earl S Ford
May 4, 2005·The Journal of Allergy and Clinical Immunology·Giamila Fantuzzi
May 4, 2005·The Journal of Allergy and Clinical Immunology·David A Beuther, E Rand Sutherland
Nov 22, 2005·Pharmacology & Therapeutics·Stephanie A Shore, Richard A Johnston
Apr 22, 2006·American Journal of Respiratory and Critical Care Medicine·David A BeutherE Rand Sutherland
Jun 6, 2006·The Journal of Allergy and Clinical Immunology·Roberto de MarcoUNKNOWN European Community Respiratory Health Survey Therapy Group
Jan 20, 2007·Journal of Applied Physiology·Dror OfirDenis E O'Donnell
Jan 2, 2008·The European Respiratory Journal·E D BatemanH J Zar
Mar 29, 2008·European Journal of Pain : EJP·Thiago M CunhaFernando Q Cunha
Jun 21, 2008·American Journal of Respiratory and Critical Care Medicine·Tim J T SutherlandD Robin Taylor
Nov 19, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Shawn D AaronUNKNOWN Canadian Respiratory Clinical Research Consortium
May 21, 2009·BMC Pulmonary Medicine·Katayoun BahadoriJ Mark FitzGerald
Jun 2, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Eun Joo LeeSe Hwa Yoo
Jun 15, 2013·Respiratory Medicine·Astrid van HuisstedeGert-Jan Braunstahl
Dec 17, 2014·Respiratory Physiology & Neurobiology·N P AleksandrovaV G Aleksandrov

❮ Previous
Next ❯

Citations

Jul 14, 2016·Multidisciplinary Respiratory Medicine·Thiago Thomaz MafortAgnaldo José Lopes
Oct 25, 2016·The Journal of Allergy and Clinical Immunology·Erick Forno
Jul 12, 2017·International Journal of Molecular Sciences·Mª Amelia Gomez-LlorenteCarolina Gomez-Llorente
Oct 11, 2017·The Journal of Spinal Cord Medicine·Palak WaliaEric Garshick
Jun 16, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Jason WeatheraldGilles Garcia
Jun 22, 2017·Current Allergy and Asthma Reports·Hayley A ScottPeter G Gibson
Nov 12, 2020·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Leticia Nabuco de Oliveira MadeiraFábio Chigres Kuschnir
Nov 20, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Chikako MotomuraShouichi Ohga
Apr 3, 2021·Cellular Immunology·Wei-Jie LiHua-Hao Shen
Dec 24, 2019·Revue des maladies respiratoires·T Villeneuve, L Guilleminault
Aug 28, 2021·International Journal of Molecular Sciences·Marina Ruxandra OteleaAgripina Rascu
Aug 2, 2021·Respiration; International Review of Thoracic Diseases·Lisa HentschJean-Paul Janssens

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.