Systemic inflammation and innate immune response in patients with previous anterior uveitis

The British Journal of Ophthalmology
M HuhtinenM Leirisalo-Repo

Abstract

To determine the presence of systemic inflammation and innate immune responsiveness of patients with a history of acute anterior uveitis but no signs of ocular inflammation at the time of recruitment. Tumour necrosis factor alpha (TNF-alpha) production in response to bacterial lipopolysaccharide (LPS) was studied using whole blood culture assay; levels of TNF-alpha in culture supernatants, and soluble interleukin 2 receptor (sIL-2R) in serum were determined by chemiluminescent immunoassay (Immulite); monocyte surface expression of CD11b, CD14, and CD16 and the proportion of monocyte subsets CD14(bright)CD16(-) and CD14(dim)CD16(+) were studied with three colour whole blood flow cytometry; and serum C reactive protein (CRP) levels were determined using immunonephelometric high sensitivity CRP assay. The CRP level (median, interquartile range) was significantly higher in 56 patients with previous uveitis than in 37 controls (1.59 (0.63 to 3.47) microg/ml v 0.81 (0.32 to 2.09) microg/ml; p=0.008). The TNF-alpha concentration of the culture media per 10(5) monocytes was significantly higher in the patient group than in the control group in the presence of LPS 10 ng/ml (1473 (1193 to 2024) pg/ml v 1320 (935 to 1555) pg/ml; p=0.012) ...Continue Reading

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Citations

Apr 2, 2003·Journal of Immunological Methods·Michiel C WarléHerold J Metselaar
Jun 24, 2003·Current Opinion in Rheumatology·Marjatta Leirisalo-RepoLeena Mattila
Oct 16, 2002·Annals of the Rheumatic Diseases·M HuhtinenM Leirisalo-Repo
Jul 1, 2005·Arthritis Research & Therapy·Sanna VähämikoKaisa Granfors
Mar 4, 2005·Scandinavian Journal of Gastroenterology·L HalmeH Repo
Mar 21, 2012·Clinical & Experimental Ophthalmology·John H ChangDenis Wakefield
Apr 5, 2014·The Journal of Pharmacy and Pharmacology·Claudio BucoloSalvatore Salomone
Jan 31, 2006·The American Journal of Medicine·Irving KushnerDavid Samols
May 4, 2016·Current Rheumatology Reports·Yael Sharon, Naomi Schlesinger
Jul 17, 2010·Acta Ophthalmologica·Marta Misiuk-HojłoStanisław Szymaniec
Aug 15, 2018·Frontiers in Immunology·Maren KasperArnd Heiligenhaus
Nov 6, 2020·European Journal of Ophthalmology·Yinon ShapiraNancy Agmon-Levin
Oct 15, 2018·American Journal of Ophthalmology·Wei-Dar ChenLi-Ju Lai
Jun 20, 2008·Journal français d'ophtalmologie·H BelguendouzC Touil-Boukoffa

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