Systemic inflammation and survival of patients with prostate cancer: evidence from the Glasgow Inflammation Outcome Study

Prostate Cancer and Prostatic Diseases
K ShafiqueD S Morrison

Abstract

There is some evidence that systemic inflammation may be associated with survival in patients with prostate cancer; however, it is unclear whether this is independent of grade. We therefore investigated the role of inflammation-based prognostic scores, the modified Glasgow Prognostic Score (mGPS) and neutrophil lymphocyte ratio (NLR), and their associations with Gleason grade in patients with prostate cancer. Patients from a cohort, the Glasgow Inflammation Outcome Study, who had diagnosis of prostate cancer, were included in this study. The mGPS was constructed by combining C-reactive protein and albumin whereas NLR by calculating the ratio of neutrophils to lymphocytes. We estimated 5-year relative survival and relative excess risk (RER) of death by mGPS and NLR categories after adjusting for age, socioeconomic circumstances and Gleason grade. In all, 897 prostate cancer patients were identified; of those 422 (47%) died during a maximum follow-up of 6.2 years. Systemic inflammation appeared to have significant prognostic value. The mGPS predicted poorer 5-year overall and relative survival independent of age, socioeconomic circumstances, disease grade and NLR. Raised mGPS also had a significant association with excess risk of...Continue Reading

References

Mar 1, 1985·Urology·P C SoganiW F Whitmore
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Apr 22, 2008·The Lancet Oncology·Simon M CollinJenny Donovan
Oct 17, 2008·Future Oncology·Sonya VastoCalogero Caruso
May 27, 2009·Carcinogenesis·Francesco ColottaAlberto Mantovani
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brandon L PierceCornelia M Ulrich
Dec 22, 2009·Future Oncology·Campbell S D Roxburgh, Donald C McMillan
Dec 29, 2009·Frontiers in Bioscience (Elite Edition)·Tommaso CastelliGiuseppe Morgia
Feb 2, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayE Steliarova-Foucher
Apr 17, 2010·Urologia Internationalis·Peter A McArdleDonald C McMillan
May 6, 2010·Technology in Cancer Research & Treatment·Hung-Chung HuangZhongming Zhao
Nov 5, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F BrayA Auvinen
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jul 5, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Michael J ProctorDonald C McMillan

❮ Previous
Next ❯

Citations

Mar 20, 2014·PloS One·Yong WeiWen-Hui Qian
Jul 6, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Masaki ShiotaSeiji Naito
Aug 11, 2015·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Amr AhmedChristian Gilfrich
Aug 19, 2015·Social Science & Medicine·Jens Klein, Olaf von dem Knesebeck
Apr 30, 2013·Brain, Behavior, and Immunity·Michael A HoytMichael R Irwin
Jun 1, 2016·International Journal of Cancer. Journal International Du Cancer·Antonella ZucchettoJerry Polesel
Dec 22, 2012·Urologia Internationalis·Jennifer M WillderJoanne Edwards
Jan 23, 2018·The Clinical Respiratory Journal·Berna Akinci OzyurekTugba Kaplan
Oct 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Ozgur Haki YukselAyhan Verit
Nov 26, 2020·Cancer·Ericka M SohlbergJohn T Leppert
May 18, 2017·Molecular Cancer Research : MCR·Irina LermanStephen R Hammes
Dec 17, 2021·Nature Communications·Sebnem Ece EksiAndrew C Adey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.