Systemic inflammation and the relationship between periodontitis, edentulism, and all-cause mortality: A 17-year prospective cohort study.

Journal of Clinical Periodontology
Lewis WinningGerard J Linden

Abstract

The aim was to investigate the role of systemic inflammation in the relationship between periodontitis, edentulism, and all-cause mortality in a group of men in Northern Ireland aged 58-72 years. A representative sample of 1558 men had a detailed dental examination between 2001 and 2003. The primary end point was death from any cause. Cox's proportional hazards model was used to assess the longitudinal relationship between periodontitis, edentulism, and all-cause mortality. Accelerated failure time modelling was performed to investigate the mediating role of systemic inflammation. Mean age of the men at baseline was 64.3 (standard deviation 2.9) years. During a median follow-up of 17 years, 500 (32.1%) men died. After adjustment for confounding variables, compared to men with no/mild periodontitis, edentulous men had a hazard ratio for all-cause mortality of 1.52 (95% confidence interval [CI] 1.16-1.99) p < .01 and for those with severe periodontitis, it was 1.34 (95% CI 1.06-1.70) p = .01. Systemic inflammation accounted only for a minor mediating pathway effect of 10%. There was evidence in this group of men that those who were edentulous or had severe periodontitis had a significantly increased risk of all-cause mortality. S...Continue Reading

References

Mar 13, 1993·BMJ : British Medical Journal·F DeStefanoC M Russell
May 1, 1997·Journal of Dentistry·P S HullJ E Clarkson
Sep 14, 1999·Journal of the American College of Cardiology·M S LauerE J Topol
Mar 21, 2000·Journal of Dentistry·I G ChestnuttM M Taylor
Apr 4, 2003·The Journal of Nutrition·Flora LubinRachel Dankner
Nov 25, 2004·International Journal of Epidemiology·Alun EvansUNKNOWN MORGAM Project
May 5, 2005·British Dental Journal·W RichardsG Higgs
Nov 10, 2005·Journal of Periodontology·Bruno G Loos
Nov 22, 2005·Lancet·Bruce L PihlstromNewell W Johnson
Sep 14, 2006·Annual Review of Psychology·David P MacKinnonMatthew S Fritz
Aug 19, 2007·Journal of Periodontology·Roy C Page, Paul I Eke
Feb 26, 2008·Journal of Clinical Periodontology·Spiros ParaskevasBruno G Loos
Mar 31, 2009·European Journal of Epidemiology·Tyler J VanderWeele
Aug 26, 2009·Journal of Clinical Periodontology·Gerard J LindenFrank Kee
Dec 15, 2010·Ageing Research Reviews·Tushar Singh, Anne B Newman
Mar 23, 2011·Psychology and Aging·Ulman LindenbergerChristopher Hertzog
Jul 28, 2012·Journal of Clinical Periodontology·Gerard J LindenChris C Patterson
May 3, 2013·Journal of Periodontology·Francesco D'AiutoJohn C Gunsolley
Mar 27, 2015·Journal of Clinical Periodontology·Birte HoltfreterUNKNOWN Joint EU/USA Periodontal Epidemiology Working Group
Aug 27, 2015·Journal of Clinical Periodontology·Lewis WinningGerard J Linden
Jul 28, 2016·Journal of Clinical Periodontology·Elsa K Delgado-AnguloWagner Marcenes
Dec 31, 2016·Journal of Clinical Periodontology·Lewis WinningGerard J Linden
Feb 10, 2017·Nature·Gökhan S Hotamisligil
Mar 18, 2017·Current Oral Health Reports·Lewis Winning, Gerard J Linden
Apr 19, 2017·Journal of Clinical Periodontology·Maurizio S TonettiJoan Otomo-Corgel
Jun 3, 2017·Epidemiology·Isabel R FulcherPaige L Williams
Mar 4, 2018·Journal of Clinical Periodontology·Kitti TorrungruangSomchai Sarujikumjornwatana
Aug 23, 2018·Journal of Clinical Periodontology·Mario RomandiniMassimo Cordaro
Oct 31, 2018·BMC Medical Research Methodology·Lauren Lapointe-ShawChaim M Bell
Feb 4, 2019·Journal of Clinical Periodontology·Lewis WinningGerard J Linden
Jul 23, 2019·Lancet·Marco A PeresRichard G Watt
Dec 7, 2019·Nature Medicine·David FurmanGeorge M Slavich
Feb 6, 2020·Journal of Clinical Periodontology·Mariano SanzGernot Wimmer
May 10, 2020·Periodontology 2000·Robert J Genco, Mariano Sanz
Oct 1, 2020·Journal of Clinical Periodontology·Lewis WinningGerard J Linden
Dec 15, 2020·Journal of the American College of Cardiology·Gregory A RothUNKNOWN GBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group
Dec 29, 2020·Journal of Clinical Periodontology·Praveen SharmaThomas Dietrich

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