PMID: 16522996Mar 9, 2006Paper

Systemic inflammation, blood pressure, and stroke outcome

The Journal of Clinical Hypertension
Mario Di Napoli, Francesca Papa

Abstract

Hypertension is the most important modifiable risk factor for ischemic stroke, and antihypertensive treatment is of paramount importance to reduce the incidence of stroke mortality and morbidity. The significance and best management of hypertension during the first hours after stroke onset, however, are still matters of debate. Cerebral ischemia results in a complex inflammatory cascade; inflammatory mechanisms are also important participants in the pathophysiology of hypertension. There has been a convergence of evidence that is important to consider in managing systemic blood pressure after stroke to ensure an optimal outcome. The identification of useful markers will allow progress in our ability to treat blood pressure in the acute phase of a stroke. The determination of levels of C-reactive protein, an acute-phase inflammation marker, may help to guide our approach in the management of blood pressure in acute ischemic stroke. Whether this target will be useful in the development of risk prediction strategies or therapies for the treatment of stroke in humans is far from clear.

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Citations

Jul 3, 2007·Current Treatment Options in Cardiovascular Medicine·Jerzy KrupinskiJosé Martínez-González
Jun 19, 2012·Translational Stroke Research·Mark FisherDavid H Cribbs
Apr 18, 2008·Current Cardiology Reports·Jerzy KrupinskiJosé Martínez-González
Dec 22, 2020·Frontiers in Neuroscience·Julie JeonHea Jin Park

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