Abstract
While recent studies have shown that patients with COPD and patients with asthma exhibit evidence of airway and systemic inflammation, markers of systemic inflammation have not been compared between the two diseases. To evaluate circulating inflammatory markers, blood was sampled from 111 patients with COPD, 75 control subjects and 46 asthmatic patients (some of whom were smokers). Measurements of WCC, serum levels of fibrinogen, high-sensitivity (hs)-CRP, IL-8, IL-6, tumour necrosis factor-alpha (TNF-alpha), transforming growth factor (TGF)-beta1, tissue inhibitors of metalloproteinase (TIMP)-1, neutrophil elastase and alpha1-antitrypsin (alpha1-AT) were performed. Serum TNF-alpha, IL-6 and TIMP-1 concentrations were significantly higher in patients with stable COPD and patients with asthma than in control patients. Serum alpha1-AT levels were significantly higher in COPD patients than in asthmatic patients and control subjects, and serum TGF-beta1 levels were higher in asthma patients than in COPD patients. Smoking status had no effect on markers in COPD and asthmatic patients. Although COPD and asthma share common markers of systemic inflammation, serum levels of TGF-beta1 and alpha1-AT may reflect differences between the di...Continue Reading
References
Jul 1, 1987·The American Review of Respiratory Disease
Jul 1, 1982·Clinical Radiology·P R GoddardI Watt
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·A YokoyamaK Hiwada
Feb 1, 1995·Chest·T MatsuseH Orimo
Sep 4, 1998·The European Respiratory Journal·K D ClarkP D Snashall
Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·R A PauwelsUNKNOWN GOLD Scientific Committee
Jul 5, 2001·Respirology : Official Journal of the Asian Pacific Society of Respirology·K Seyama
Apr 30, 2002·Diabetes·Dilys J FreemanUNKNOWN West of Scotland Coronary Prevention Study
Nov 13, 2002·Circulation·G EngströmF Lindgärde
Mar 1, 2003·The European Respiratory Journal·A G N AgustíX Busquets
Mar 26, 2003·Circulation·Don D Sin, S F Paul Man
Dec 19, 2003·The European Respiratory Journal·I GodoyS A R Paiva
Jan 17, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·P LindB Hedblad
Apr 30, 2004·Thorax·M Needham, R A Stockley
Jun 30, 2004·Thorax·W Q GanD D Sin
Jan 27, 2005·European Heart Journal·Cezary SzmigielskiZbigniew Gaciong
Feb 12, 2005·Chest·Wen Qi GanDon D Sin
May 3, 2005·The European Respiratory Journal·Y HigashimotoH Itoh
Feb 4, 2006·The European Respiratory Journal·J P de TorresC Casanova
May 19, 2006·The European Respiratory Journal·E F M Wouters
May 19, 2006·The European Respiratory Journal·M TakemuraM Mishima
Citations
Jul 30, 2009·Current Opinion in Allergy and Clinical Immunology·Stefano Guerra
Aug 10, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mathilde LeclereJean-Pierre Lavoie
Aug 29, 2009·American Journal of Respiratory and Critical Care Medicine·Niki FensPeter J Sterk
Apr 24, 2009·Respiratory Research·Joanna L RichensPaul O'Shea
Jan 8, 2011·BMC Genomics·Mainul HusainNiel A Karrow
Jun 11, 2010·Journal of Inflammation·Suzana E TanniIrma Godoy
Apr 9, 2013·PloS One·István IvancsóLilla Tamási
May 14, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Umme KolsumDave Singh
Sep 8, 2011·International Journal of Medical Sciences·Yoko ShibataIsao Kubota
Sep 4, 2015·PeerJ·Jia WeiDe-Yun Cheng
Apr 11, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M MonadiM Amiri
Jun 19, 2013·Respiratory Medicine·Elie DonathLouis Lit
Feb 22, 2012·Veterinary Immunology and Immunopathology·Anouk Lavoie-LamoureuxJean-Pierre Lavoie
Apr 1, 2017·Molecular Neurobiology·David A BuckleyPatrick C McHugh
Dec 6, 2008·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G Egger, J Dixon
Jan 30, 2009·American Journal of Industrial Medicine·Allen G Kraut
Apr 25, 2014·PloS One·Younis M KhanIan M Adcock
Sep 14, 2019·Experimental Lung Research·Keitaro NakamotoHajime Takizawa
Nov 21, 2016·Inflammation·Jae-Won LeeKyoung-Seop Ahn
May 1, 2021·International Journal of Clinical Practice·Talat KilicOmer Kaya