Systemic inflammation in chronic obstructive pulmonary disease and asthma: Similarities and differences

Respirology : Official Journal of the Asian Pacific Society of Respirology
Yuji HigashimotoHidekazu Itoh

Abstract

While recent studies have shown that patients with COPD and patients with asthma exhibit evidence of airway and systemic inflammation, markers of systemic inflammation have not been compared between the two diseases. To evaluate circulating inflammatory markers, blood was sampled from 111 patients with COPD, 75 control subjects and 46 asthmatic patients (some of whom were smokers). Measurements of WCC, serum levels of fibrinogen, high-sensitivity (hs)-CRP, IL-8, IL-6, tumour necrosis factor-alpha (TNF-alpha), transforming growth factor (TGF)-beta1, tissue inhibitors of metalloproteinase (TIMP)-1, neutrophil elastase and alpha1-antitrypsin (alpha1-AT) were performed. Serum TNF-alpha, IL-6 and TIMP-1 concentrations were significantly higher in patients with stable COPD and patients with asthma than in control patients. Serum alpha1-AT levels were significantly higher in COPD patients than in asthmatic patients and control subjects, and serum TGF-beta1 levels were higher in asthma patients than in COPD patients. Smoking status had no effect on markers in COPD and asthmatic patients. Although COPD and asthma share common markers of systemic inflammation, serum levels of TGF-beta1 and alpha1-AT may reflect differences between the di...Continue Reading

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Citations

Jul 30, 2009·Current Opinion in Allergy and Clinical Immunology·Stefano Guerra
Aug 10, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mathilde LeclereJean-Pierre Lavoie
Aug 29, 2009·American Journal of Respiratory and Critical Care Medicine·Niki FensPeter J Sterk
May 14, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Umme KolsumDave Singh
Sep 8, 2011·International Journal of Medical Sciences·Yoko ShibataIsao Kubota
Apr 11, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M MonadiM Amiri
Feb 22, 2012·Veterinary Immunology and Immunopathology·Anouk Lavoie-LamoureuxJean-Pierre Lavoie
Dec 6, 2008·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G Egger, J Dixon
Jan 30, 2009·American Journal of Industrial Medicine·Allen G Kraut
May 1, 2021·International Journal of Clinical Practice·Talat KilicOmer Kaya

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