Systemic Inflammation in Severe Obese Patients Undergoing Surgery for Obesity and Weight-Related Diseases

Obesity Surgery
Wilson R FreitasCarlos A Malheiros

Abstract

Obesity is a worldwide disease related to genetic, environmental, and behavioral factors, and it is associated with high rates of morbidity and mortality. Recently, obesity has been characterized by a low-grade inflammatory state known as inflammome indicated by chronic increases in circulating concentrations of inflammatory markers. The purpose of this study was to evaluate the effect of weight loss induced by surgery for obesity and weight-related diseases on pro-inflammatory cytokine (TNF-α) and anti-inflammatory adipokine (adiponectin) levels, and on an adipose-derived hormone (leptin) in severely obese subjects. This randomized, controlled trial involved 55 severe obese patients (50 women, age 18-63 years, and body mass index of 35.7-63 kg/m2) who underwent bariatric surgery (BS). Patients with a BMI > 65 kg/m2 and clinical and mental instability, or significant and unrealistic expectations of surgery were excluded. Blood samples were collected during the fasting period to analyze tumor necrosis factor alpha (TNF-α), adiponectin, and leptin levels by enzyme-linked immunosorbent assay. At baseline, no significant difference was observed in the anthropometric, demographic, clinical characteristics and biochemistry and inflam...Continue Reading

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Citations

Jun 6, 2019·Acta Cirúrgica Brasileira·Miguel Luiz Antônio ModolinRolf Gemperli
May 1, 2019·Obesity Surgery·Marcella Rodrigues GuedesMárcia Regina Simas Torres Klein
Feb 1, 2019·Journal of Thrombosis and Thrombolysis·Armando TripodiFlora Peyvandi
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Jul 21, 2020·Current Opinion in Pharmacology·Justine FaramiaAndré Tchernof
Jul 8, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·De-Feng LiuJing Dong
Jan 16, 2022·Cytokine·Merve Zeytinli AksitMustafa Emiroglu

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
gastric bypass

Software Mentioned

Statistical Package for Social Sciences

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