Systemic inflammatory markers in relation to lung function in NHANES. 2007-2010

Respiratory Medicine
Elisabet NerpinAndrei Malinovschi

Abstract

Low-grade systemic inflammation, mainly assessed by C-reactive protein (CRP), has been associated with impaired lung function. Few studies have studied if CRP, blood eosinophils, and blood neutrophils offer additive information in relation to lung function. To analyse associations between lung function and CRP, blood eosinophils, and blood neutrophils, with special regard to additive information of combining the inflammatory markers. Cross-sectional study on 7753 participants, 20-80 years of age, in the National Health and Nutrition Examination Survey. Gender-based tertiles for CRP, blood eosinophils, and blood neutrophils were analysed in relation to the following lung function parameters: forced expiratory volume in 1 s (FEV1% predicted), forced vital capacity (FVC % predicted), and FEV1/FVC ratio. CRP, blood eosinophils, and blood neutrophils levels were inversely related to FEV1 and FVC. Only blood eosinophils and blood neutrophils were inversely related to FEV1/FVC ratio. Further, lower lung function was found with increased number of elevated inflammatory markers in the highest tertile (one, two or three vs. non elevated) for FEV1 (β-coeff., -2.20, -4.43, and -6.43, p < 0.001) and FVC (β-coeff., -1.70, -3.15 and -5.33, p ...Continue Reading

Citations

Mar 30, 2020·Journal of Occupational and Environmental Medicine·Sheena E MarteniesSheryl Magzamen
Feb 20, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Maria ÖdlingInger Kull
Mar 25, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Sara M Mensink-BoutLiesbeth Duijts
Aug 28, 2021·International Journal of Environmental Research and Public Health·Xuejie WangEsther Barreiro
Jun 27, 2021·The European Respiratory Journal·Victoria S BensonNamhee Kwon

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