Systemic Inflammatory Response and Multiple Organ Dysfunctions Following Crush Injury: a New Experimental Model in Rabbits

Inflammation
Peng XuWang-Xiang Jiang

Abstract

In this study, we aim to develop a new, reproducible crush injury (CI) model in rabbits. Anesthetized rabbits were compressed on both hind limbs using a special instrument for 6 h followed by 3 h of reperfusion. Blood samples and injured muscles were collected for biochemical analysis and morphological evaluation. Survival observation lasted for 72 h. Bilateral compressions with 10 kg/kg body weight (BW), but not with 5 kg/kg BW, reduced serious systemic impairment. Bilateral compressions with 10 kg/kg BW resulted in severe lactic acidosis; increased serum K+, creatine phosphokinase, aspartate transaminase, alanine transaminase, blood urea nitrogen, and creatinine levels; and a sharply decreased mean arterial blood pressure after compression release. Serious tissue edema and inflammation were observed in the damaged muscles. The mortality rates in compression groups were 20% (5 kg/kg BW) and 60% (10 kg/kg BW). There was a significant increase in plasma concentrations of TNF-α and IL-1β after compression. Plasma IL-1β levels returned to control levels at 6 h after compression release, whereas TNF-α peaked at 12 h following reperfusion. Furthermore, antiinflammatory cytokines, including IL-4 and IL-10, were also increased after c...Continue Reading

References

Sep 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R VanholderN Lameire
Dec 12, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·O DönmezO Durmaz
Jan 5, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ekrem ErekUNKNOWN Turkish Study Group of Disaster
Nov 21, 2002·Critical Care Medicine·Mehmet Sukru SeverNorbert Lameire
Jan 28, 2005·The Journal of Trauma·Pavel AkimauHisashi Sugimoto
Mar 10, 2006·The New England Journal of Medicine·Mehmet Sukru SeverNorbert Lameire
Nov 10, 2009·Critical Care : the Official Journal of the Critical Care Forum·Wenfang LiZhaofen Lin
Sep 2, 2010·Nephron. Clinical Practice·R VanholderR Wainstein
May 26, 2011·The Journal of Trauma·Qiang HeLi Wang
Jun 15, 2012·The Journal of Trauma and Acute Care Surgery·Isamu MurataJun Kobayashi
Sep 7, 2012·Advances in Clinical Chemistry·Anastassios PhilippouMichael Koutsilieris
Mar 26, 2014·Innate Immunity·Jennifer NicholasBarbara St Pierre Schneider

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Citations

Jul 20, 2019·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Xian-Long ZhouYan Zhao
Apr 4, 2021·Biomolecules·Sarah A WalshThomas A Davis
Aug 16, 2021·Journal of Pharmaceutical and Biomedical Analysis·Simone KönigFrank Birklein

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