Systemic Inflammatory Response Markers and CA-125 Levels in Ovarian Clear Cell Carcinoma: A Two Center Cohort Study

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Hee Seung KimYong Sang Song

Abstract

We compared the predictive and prognostic values of leukocyte differential counts, systemic inflammatory (SIR) markers and cancer antigen 125 (CA-125) levels, and identified the most useful marker in patients with ovarian clear cell carcinoma (OCCC). The study included 109 patients with OCCC who did not have any inflammatory conditions except endometriosis, and underwent primary debulking surgery between 1997 and 2012. Leukocyte differential counts (neutrophil, lymphocyte, monocyte, eosinophil, basophil, and platelet), SIR markers including neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), and platelet to lymphocyte ratio (PLR), and CA-125 levels were estimated to select potential markers for clinical outcomes. Among potential markers (neutrophil, monocyte, platelet, NLR, MLR, PLR, and CA-125 levels) selected by stepwise comparison, CA-125 levels were best at predicting advanced stage disease, suboptimal debulking and platinum-resistance (cut-off values, ≥ 46.5, ≥ 11.45, and ≥ 66.4 U/mL; accuracies, 69.4%, 78.7%, and 68.5%) while PLR ≥ 205.4 predicted non-complete response (CR; accuracy, 71.6%) most accurately. Moreover, PLR < 205.4 was an independent factor for the reduced risk of non-CR (adjusted odds ...Continue Reading

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Citations

Nov 2, 2016·Cancer Biomarkers : Section a of Disease Markers·E Sun PaikDuk-Soo Bae
Jul 28, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Boyun KimYong Sang Song
May 22, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jun ZhuXingzhu Ju
Aug 28, 2018·Technology in Cancer Research & Treatment·Gaowen ChenYifeng Wang
Aug 14, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Julie My Van NguyenGeneviève Bouchard-Fortier
Sep 4, 2015·Biomarkers in Cancer·Ghazala KhanBarbara-Ann Guinn
Mar 6, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Anastasia ProdromidouVasilios Pergialiotis
Oct 3, 2019·Journal of Gynecologic Oncology·Kosuke YoshidaFumitaka Kikkawa
Jul 20, 2021·Cancer Management and Research·Michal MlekoTomasz Banas
Aug 19, 2021·Journal of Clinical Laboratory Analysis·Ting ChenShun-Yu Hou

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Methods Mentioned

BETA
biopsy

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