Systemic inflammatory response syndrome and surgical stress in thoracic surgery

Journal of Critical Care
Kazumasa TakenakaToshiki Hirata

Abstract

To evaluate the clinical usefulness of postoperative systemic inflammatory response syndrome (SIRS) as an index of surgical stress in patients undergoing thoracic surgery. Forty-five consecutive patients who underwent thoracic surgery with thoracotomy were enrolled. The SIRS criteria were examined daily during the first 7 postoperative days. The serum interleukin-6 (IL-6) level, operation time, intraoperative blood loss, amount of thoracic drainage, and C-reactive protein levels were also measured. Sixteen cases were categorized into the SIRS group, whereas 29 cases were categorized into the non-SIRS group. Among the patients who underwent thoracic surgery, the physiological responses of the patients to the surgery, such as serum IL-6 levels and C-reactive protein levels, were significantly higher in the SIRS group than in the non-SIRS group (P = .002 and .024, respectively). The serum IL-6 level on the first postoperative day was an independent factor associated with SIRS (95% CI 1.002-1.041; P = .030). Furthermore, there was a correlation between the number of SIRS days and the duration of the postoperative hospital stay (r = 0.379, P = .012). Our results demonstrated that SIRS reflected the degree of surgical stress, especia...Continue Reading

Associated Clinical Trials

References

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Citations

Apr 17, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Lee W JonesTony Reiman
Jun 21, 2011·Critical Care : the Official Journal of the Critical Care Forum·Allison SutherlandDeon Venter
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Feb 22, 2012·ISRN Cardiology·C ChelazziA R De Gaudio
Dec 6, 2014·BMJ Open Respiratory Research·Richard O JonesA John Simpson
Aug 4, 2015·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Masae IwasakiDaqing Ma
Sep 30, 2015·Journal of Cardiovascular Medicine·Alessandro ParolariElena Tremoli
Mar 22, 2008·BioFactors·Takuma TsukiokaShigefumi Suehiro
Feb 5, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Thijs C D RettigPeter G Noordzij
Jul 26, 2012·Clinical Biochemistry·Chiara CaselliDaniela Giannessi
Dec 19, 2017·Anesthesia and Analgesia·Anis John KadadoJoseph G Akar
Jan 22, 2019·Anesthesiology·MiHye ParkIn Sun Song
Oct 3, 2019·Anesthesiology·MiHye Park, Hyun Joo Ahn
Feb 27, 2020·Korean journal of anesthesiology·Hyun Joo AhnEun-Ho Lee
Jan 25, 2018·Annals of the Royal College of Surgeons of England·Pjj HerrodJ N Lund
Aug 18, 2020·Mediators of Inflammation·Xiang ZhangJun Zhang
Aug 11, 2018·Biomarker Insights·Sara Bobillo-PerezIolanda Jordan Garcia

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