Systemic Inflammatory Response Syndrome Is a Major Determinant of Cardiovascular Outcome in Takotsubo Syndrome

Circulation Journal : Official Journal of the Japanese Circulation Society
Lucie Lachmet-ThébaudOlivier Morel

Abstract

Recent insights have emphasized the importance of inflammatory response in takotsubo syndrome (TTS). We sought to evaluate the predictors of systemic inflammatory response syndrome (SIRS) and its impact on cardiovascular mortality after TTS.Methods and Results:The 215 TTS patients were retrospectively included between September 2008 and January 2018. SIRS was diagnosed in 96 patients (44.7%). They had lower left ventricular ejection fraction (LVEF) on admission (34.5% vs. 41.9%; P<0.001) and higher peak brain natriuretic peptide and troponin. At a median follow-up of 518 days, SIRS was associated with increased in-hospital mortality (14.6% vs. 5.0%; P=0.019), overall mortality (29.4% vs. 10.8%; P=0.002), and cardiovascular mortality (10.6% vs. 2.1%; P=0.026). A history of cancer (OR, 3.36; 95% CI: 1.54-7.31; P=0.002) and LVEF <40% at admission (OR, 2.31; 95% CI: 1.16-4.58; P=0.017) were identified as independent predictors of SIRS. On multivariate Cox regression analysis, SIRS (HR, 12.8; 95% CI: 1.58-104; P=0.017), age (HR, 1.09; 95% CI: 1.02-1.16; P=0.01), and LVEF <40% at discharge (HR, 9.88; 95% CI: 2.54-38.4; P=0.001) were independent predictors of cardiovascular death. SIRS was found in a large proportion of TTS patients a...Continue Reading

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Citations

Sep 19, 2020·Journal of Clinical Medicine·Charlotte DagrenatOlivier Morel
Apr 29, 2020·Trends in Cardiovascular Medicine·Thanh H NguyenJohn D Horowitz
Apr 9, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Kensuke MatsushitaOlivier Morel
Aug 11, 2021·ESC Heart Failure·Xiaojia LuBin Wang

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