PMID: 9240130Jul 1, 1997Paper

Systemic inflammatory response syndrome

The British Journal of Surgery
M G Davies, P O Hagen


Localized inflammation is a physiological protective response which is generally tightly controlled by the body at the site of injury. Loss of this local control or an overly activated response results in an exaggerated systemic response which is clinically identified as systemic inflammatory response syndrome (SIRS). Compensatory mechanisms are initiated in concert with SIRS and outcome (resolution, multiple organ dysfunction syndrome or death) is dependent on the balance of SIRS and such compensatory mechanisms. No directed therapies have been successful to date in influencing outcome. This review examines the current spectrum and pathophysiology of SIRS. Further clinical and basic scientific research is required to develop the global picture of SIRS, its associated family of syndromes and their natural histories.


Jan 1, 1978·CRC Critical Reviews in Microbiology·F M Collins
Jan 1, 1992·Advances in Experimental Medicine and Biology·B J NelsonC A Nacy
Nov 1, 1992·Journal of Reconstructive Microsurgery·K Ley
Aug 1, 1992·Digestive Diseases and Sciences·S A McClaveH L Snider
Sep 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Z M Quezado, C Natanson
Apr 23, 1992·The New England Journal of Medicine·H S WarrenR S Munford
Jun 1, 1992·The American Review of Respiratory Disease·A F SuffrediniJ E Parrillo
Feb 11, 1991·Current Opinion in Immunology·C F Nathan, J B Hibbs
Jan 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S D Cushing, A M Fogelman
Oct 1, 1991·The Journal of Clinical Investigation·N A NelkenJ N Wilcox
Sep 15, 1991·Annals of Internal Medicine·J E Parrillo
Sep 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J M WangA Mantovani
Sep 30, 1991·The American Journal of Medicine·G R Bernard
Mar 1, 1991·The American Review of Respiratory Disease·D R DantzkerG Gutierrez
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S Ylä-HerttualaD Steinberg
Jun 7, 1990·The New England Journal of Medicine·T van der PollJ W ten Cate
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R G KilbournR F Lodato
Sep 21, 1990·Science·R R SchumannR J Ulevitch
Sep 1, 1986·The Journal of Experimental Medicine·P S TobiasR J Ulevitch
Sep 30, 1988·Biochemical and Biophysical Research Communications·R M StrieterS L Kunkel
Aug 3, 1989·The New England Journal of Medicine·A F SuffrediniJ E Parrillo
Sep 1, 1989·Mayo Clinic Proceedings·D W Swank, S B Moore
Jun 9, 1988·The New England Journal of Medicine·H R MichieD W Wilmore
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·I C KettelhutA L Goldberg
Nov 30, 1988·Biochemical and Biophysical Research Communications·J B HibbsE M Rachlin
Jan 1, 1988·Free Radical Biology & Medicine·G M Rubanyi
Apr 1, 1988·Infection and Immunity·D T GolenbockR A Proctor
May 1, 1988·The Journal of Clinical Investigation·X M Sun, W Hsueh
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P P NawrothD M Stern
Sep 1, 1986·Infection and Immunity·J J ChaseE Ribi
Oct 24, 1986·Science·K J TraceyJ D Albert
Jan 1, 1984·Reviews of Infectious Diseases·C A Dinarello
Nov 11, 1982·The New England Journal of Medicine·E J ZieglerA I Braude
Sep 1, 1982·The Journal of Clinical Investigation·E R JacobsF C Hiller
Sep 1, 1981·The Journal of Experimental Medicine·M Kawakami, A Cerami
Dec 1, 1995·Current Problems in Surgery·C C Baker, M D Huynh
Jan 1, 1994·Advances in Pharmacology·C Thiemermann
Jan 1, 1995·The Annals of Pharmacotherapy·T A Wolfe, J F Dasta
Feb 1, 1995·Clinical Science·H F GoodeN R Webster
Jul 1, 1995·American Journal of Respiratory and Critical Care Medicine·P C RidingsA A Fowler
Aug 1, 1995·American Journal of Respiratory Cell and Molecular Biology·P E ParsonsG S Worthen
Jan 1, 1995·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·D T Graves, Y Jiang
Jul 1, 1995·Intensive Care Medicine·S M YentisJ Sheldon
Jul 1, 1995·The Journal of Trauma·P C RidingsH J Sugerman
Mar 1, 1995·Intensive Care Medicine·S Fujishima, N Aikawa
Jun 1, 1995·Journal of Leukocyte Biology·H A Pereira
Aug 1, 1993·British Heart Journal·A J Brady, P A Poole-Wilson
Jan 1, 1994·Annual Review of Medicine·T R ZieglerD W Wilmore
Nov 1, 1993·Annals of Surgery·M G Davies, P O Hagen
Sep 1, 1993·Mayo Clinic Proceedings·M M McMahonM J Murray
Nov 1, 1995·European Journal of Clinical Investigation·M GawazK Werdan
Jul 1, 1996·Critical Care Medicine·R C Bone
Jan 1, 1995·Journal of Cardiovascular Pharmacology·W Graninger, C Wenisch
Apr 1, 1996·Nutrition·E M Conner, M B Grisham


May 19, 2000·The Proceedings of the Nutrition Society·L O'Flaherty, D J Bouchier-Hayes
Oct 9, 2001·Scandinavian Journal of Gastroenterology·Marja-Leena Kylänpää-BäckH Repo
Jun 19, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·P Silver
Mar 20, 2004·Irish Journal of Medical Science·Y GotoG D Shorten
Oct 3, 2006·Current Opinion in Anaesthesiology·G Deby-DupontM Lamy
Oct 25, 2006·Annual Review of Physiology·Ashok K SalujaVikas Dudeja
Jul 10, 2007·Journal of Feline Medicine and Surgery·Martina GreinerKatrin Hartmann
Oct 10, 2007·Inflammation·M RemichkovaP Dimitrova
Apr 21, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marlene E StarrHiroshi Saito
Jan 13, 2010·Journal of Cardiothoracic Surgery·Efstratios ApostolakisGeorgios S Papadopoulos
Dec 1, 2009·Surgical Infections·Philip S BarieSoumitra R Eachempati
Nov 29, 2016·The Journal of Trauma and Acute Care Surgery·Tyler J LoftusAlicia M Mohr
Jan 19, 2017·The Journal of Trauma and Acute Care Surgery·Tyler J LoftusJaneen R Jordan
Apr 15, 2017·Surgical Endoscopy·Tyler J LoftusWilliam J Zingarelli
Dec 20, 2018·Frontiers in Physiology·Genny RaffaeliGiacomo Cavallaro
Mar 27, 2019·Therapeutic Delivery·Maryam A Shetab Boushehri, Alf Lamprecht
Apr 30, 2019·Journal of Veterinary Emergency and Critical Care·Lindsey NielsenArmelle de Laforcade
Oct 2, 2019·Frontiers in Pediatrics·Katherine CashenHeidi Dalton
Apr 2, 2020·Surgery Research and Practice·Paulo Roberto Rodrigues BicalhoFernando de Sá Silva
Aug 9, 2020·Frontiers in Veterinary Science·Jiafeng DingHongbin Wang
Feb 13, 2001·The British Journal of Surgery·Marja-Leena Kylänpää-BäckH Repo
Jan 18, 2003·World Journal of Gastroenterology : WJG·En-Qiang MaoSheng-Dao Zhang
May 15, 2002·Addiction Biology·Marja-Leena Kylänpää-BäckE Kemppainen
Apr 10, 2002·Critical Care Medicine·Guy L CliftonHarvey S Levin
Oct 30, 2003·Drug and Chemical Toxicology·Helio VannucchiAlceu Afonso Jordão Júnior
Jan 27, 2006·World Journal of Gastroenterology : WJG·Nestor González-RoldánArmando Isibasi
Nov 14, 2008·American Journal of Physiology. Renal Physiology·Josefin AxelssonBengt Rippe
Jul 10, 2009·American Journal of Physiology. Renal Physiology·Josefin AxelssonBengt Rippe
Feb 13, 2009·The Journal of Pharmacology and Experimental Therapeutics·Yuk Cheung Chan, Po Sing Leung
Dec 18, 2013·Antioxidants & Redox Signaling·Shivanjali Joshi-BarrAdah Almutairi
Apr 1, 2010·Indian Journal of Clinical Biochemistry : IJCB·Surupa BasuA Majumdar
Jul 28, 2019·Intensive Care Medicine Experimental·Abdulrahman Al-FaresLorenzo Del Sorbo
Jun 27, 2019·Critical Care : the Official Journal of the Critical Care Forum·Carlo CustoderoRobert T Mankowski
Dec 5, 2019·Frontiers in Behavioral Neuroscience·Clivandir Severino da SilvaAna Teresa Figueiredo Stochero Leslie
Jul 28, 2020·Journal of Clinical Medicine·Philipp KobbeFrank Hildebrand
Oct 30, 1998·The Proceedings of the Nutrition Society·B J Rowlands, K R Gardiner
Jan 31, 2002·World Journal of Gastroenterology : WJG·Q P Chen
Aug 7, 2002·Critical Care Medicine·José M Alonso de VegaLuis F Carbonell
Aug 26, 1998·The British Journal of Surgery·B KavukluI Sayek
Mar 23, 2006·Shock·Martijn van GriensvenHans-Christoph Pape
Sep 3, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Louis W C ChowCarter Cheng
Sep 10, 2005·The Journal of Burn Care & Rehabilitation·Areta Kowal-VernDavid B Rubin
Jan 11, 2000·Critical Care Medicine·M O SimovicJ A Windsor
Jan 10, 2002·Journal of Clinical Gastroenterology·Y W Novitsky, M P Callery
Mar 21, 2006·Current Opinion in Anaesthesiology·Christine Rinder
Dec 31, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jeffrey R ScottRichard F Potter
May 20, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Luca AldrighettiGianfranco Ferla
Dec 13, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Robert B DormanRobert W Brock
Jul 27, 2012·Interactive Cardiovascular and Thoracic Surgery·Mariateresa GiglioNicola Brienza
Dec 3, 2013·World Journal of Emergency Surgery : WJES·Massimo SartelliFausto Catena
Mar 5, 2013·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Thomas C Watkins, Christopher T Clark
Sep 16, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Elizabeth S B BarroqueiroRosane N M Guerra
Jan 5, 2017·World Journal of Surgery·Tyler J LoftusAlicia M Mohr
Nov 29, 2016·Critical Care : the Official Journal of the Critical Care Forum·Jonathan E MillarJohn F Fraser
Jan 26, 2018·The Journal of Trauma and Acute Care Surgery·Tyler J LoftusJaneen R Jordan
Mar 24, 2018·Electrophoresis·Raj Poovindran AnadaDharmendra Ganesan
Aug 15, 2017·World Journal of Emergency Surgery : WJES·Arianna BirindelliFausto Catena
Sep 22, 2018·Annals of Gastroenterological Surgery·Satoshi OnoSuefumi Aosasa
Aug 11, 2018·Biomarker Insights·Sara Bobillo-PerezIolanda Jordan Garcia
Jan 19, 2002·Annals of the New York Academy of Sciences·W H FissellH D Humes
May 5, 2004·Journal of Leukocyte Biology·Joanne L Lomas-NeiraAlfred Ayala
Dec 8, 2004·Seminars in Cardiothoracic and Vascular Anesthesia·J Nana Ghansah, J Thomas Murphy
Feb 11, 2003·Critical Care Medicine·Staffan Holbeck, Per-Olof Grände
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aideen Byrne, Denis J Reen
Oct 1, 2010·Inflammation·Ricardo Obalski de MelloJarbas Rodrigues de Oliveira
Sep 4, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·J A Viedma Contreras
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Neeloffer MookherjeeRobert E W Hancock
Dec 29, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Carlo PulitanòLuca Aldrighetti
Dec 31, 2003·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·S WittmannD Fröhlich
Apr 21, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jundong DuZhanliang Li
May 4, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Won Fen WongMasanobu Satake
Sep 12, 2015·Journal of Applied Physiology·Karol DokladnyPope L Moseley
Sep 8, 2012·Scandinavian Journal of Gastroenterology·Sanna MeriläinenTatu Juvonen
Jan 21, 2018·World Journal of Surgery·Tyler J LoftusScott C Brakenridge
Apr 15, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Lei ShenZhimin Yin
Sep 13, 2017·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hayata MaedaKenichi Matsuda
Dec 20, 2019·The Journal of Trauma and Acute Care Surgery·Tyler J LoftusScott C Brakenridge
Sep 20, 2007·International Journal of Experimental Pathology·Manuel A MansoIsabel De Dios
Mar 26, 2005·Surgical Endoscopy·Y W NovitskyM P Callery
Dec 4, 2014·World Journal of Gastroenterology : WJG·Natasha IrreraDomenica Altavilla
Nov 28, 2012·Advanced Healthcare Materials·Volker PresserYury Gogotsi
Nov 10, 2007·Medicinski pregled·Zorica JovanovićSlobodan Janković
Jun 25, 2009·Journal of Cardiac Surgery·Efstratios ApostolakisDimitris Dougenis
May 23, 2006·Critical Care Medicine·Peter Gosling
Nov 3, 2004·The British Journal of Surgery·P MentulaH Repo
Jan 15, 2021·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Margo A PeytonThuy L Ngo
Jan 21, 2021·Journal of Clinical Medicine·Debdipto MisraVida Abedi
Mar 5, 2021·Journal of Cellular and Molecular Medicine·Lu WangLichao Hou
Sep 19, 2006·Shock·Rosanna Di PaolaSalvatore Cuzzocrea
Jun 5, 2017·Redox Biology·Andrey V KozlovAdelheid Weidinger
Aug 31, 2020·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Anil SachdevParul Chugh
Jul 18, 2000·The Journal of Surgical Research·R Anup, K A Balasubramanian

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