Systemic involvement in mycosis fungoides

Clinics in Dermatology
Günter Burg

Abstract

Mycosis fungoides (MF) represents almost 50% of all primary cutaneous lymphomas and more than 70% of cutaneous T-cell lymphomas (CTCL). Arising from preferentially skin-homing lymphocytes with genetic instability, MF evolves through stages (IA-IVB), producing inconspicuous inflammatory features in the beginning and finally resulting in a proliferation of cytomorphologic, phenotypic, and genotypic abnormal tumor cells. Over the past 200 years, there has been much confusion in the classification of lymphomas due to semantic disagreements (MF, CTCL, parapsoriasis, lymphosarcoma, reticulum cell sarcoma, and many other terms), lack of diagnostic standard criteria, and new molecular diagnostic methods. Studies on extracutaneous involvement in early stages (IA-IIA) are almost completely lacking. In advanced stages of MF (IIB-IVB), discovery of extracutaneous involvement is dependent on the methods used (physical examination, technology, molecular diagnostics, autopsy, and laparoscopy) and reveals a wide range of results. Due to the inflammation-simulating features in the beginning of the disease, early diagnosis is very difficult to assess. Extracutaneous involvement has previously been documented in more than 70% of autopsies. More r...Continue Reading

References

Apr 1, 1979·Cancer·A F HoodJ V Hunt
Feb 1, 1978·Journal of Cutaneous Pathology·A M WormK Thomsen
Sep 1, 1976·The American Journal of the Medical Sciences·C D PetersenJ E Kurnick
Jan 1, 1992·International Archives of Allergy and Immunology·S Romagnani
Nov 1, 1991·Annals of Epidemiology·M A Weinstock
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Jul 1, 1988·JAMA : the Journal of the American Medical Association·M A Weinstock, J W Horm
Mar 1, 1986·The British Journal of Dermatology·H J SentisW A van Vloten
Jan 1, 1987·The British Journal of Dermatology·N J SlevinI D Todd
Feb 1, 1966·The Journal of Experimental Zoology·R Rappaport
Oct 1, 1974·Cancer·H Rappaport, L B Thomas
Jun 1, 1974·Cancer·D VariakojisH Rappaport
Sep 1, 1974·Cancer·B Erkman-Balis, H Rappaport
Jan 1, 1972·Naika. Internal medicine·H IkemotoK Sagawa
Nov 1, 1966·Archives of Dermatology·D P CyrG H Worsley
Feb 1, 1970·The British Journal of Dermatology·I Caldwell, A D Dayan
Mar 1, 1971·Archives of Otolaryngology·A M CohnH Rappaport
Aug 1, 1982·The British Journal of Dermatology·L HammingaW A Van Vloten
Feb 1, 1982·Archives of Dermatology·D B CzarneckiT O'Brien
Dec 1, 1995·The American Journal of Surgical Pathology·B R SmollerM Hendrickson
Jan 1, 1994·Archives of Dermatological Research·K Thestrup-Pedersen, K Kaltoft
Sep 1, 1994·Clinical Immunology and Immunopathology·K W Wucherpfennig
Mar 1, 1996·Immunology Today·T R Mosmann, S Sad
May 30, 1998·International Journal of Oral and Maxillofacial Surgery·T HataM Hosoda
May 15, 1998·The British Journal of Dermatology·K R ChenS Miyakawa
Mar 10, 1999·Journal of the American Academy of Dermatology·H S ZackheimA McMillan
Apr 29, 2000·Neurologia Medico-chirurgica·H OishiM Abe
Mar 22, 2001·The British Journal of Dermatology·L A FearfieldC B Bunker
May 7, 2004·The New England Journal of Medicine·Michael GirardiLynn D Wilson
Dec 18, 2004·Dermatology : International Journal for Clinical and Investigative Dermatology·R DummerUNKNOWN Task Force Skin Cancer
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Nov 19, 2005·Journal of Cutaneous Pathology·Günter BurgSean Whittaker
Nov 29, 2005·Journal of the American Academy of Dermatology·Nicola PimpinelliUNKNOWN International Society for Cutaneous Lymphoma

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Citations

Sep 1, 2015·Clinics in Dermatology·Nikolai TsankovRazvigor Darlenski
Feb 11, 2020·Leukemia & Lymphoma·Milena KohnCatherine Thieblemont
Dec 21, 2016·Current Hematologic Malignancy Reports·Anh PhanMary Jo Lechowicz
Dec 28, 2019·Seminars in Diagnostic Pathology·Nadine S Aguilera, Aaron Auerbach
Nov 18, 2020·Seminars in Diagnostic Pathology·Osvaldo PadillaJulia T Geyer
Aug 27, 2021·International Journal of Dermatology·Denis Miyashiro, José A Sanches

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