PMID: 11334202May 4, 2001Paper

Systemic leukocyte filtration during cardiopulmonary bypass

Perfusion
A FabbriG Nardon

Abstract

Cardiopulmonary bypass (CPB) induces a whole body inflammatory response leading to postoperative lung dysfunction. Activated leukocytes may play a role in the pathogenesis of pulmonary dysfunction. We evaluated postoperative lung function after the use of leukocyte-depleting filters incorporated in the extracorporeal circuit during CPB. From November 1997 to March 2000, 40 patients underwent isolated coronary artery bypass grafting. Patients were randomly allocated to the leukocyte-depletion group (group F, 20 patients) or to the control group (group C, 20 patients). There was no significant difference between the two groups with respect to age, sex, weight, height, body surface area, haemoglobin and haematocrit levels, preoperative left ventricular ejection fraction, cooling temperature, aortic crossclamping and CBP duration. Blood samples were drawn preoperatively, at aortic declamping, 60 min after CPB, after arriving at the intensive care unit (ICU) and 24 h after the operation. We analysed blood cell count, elastase, interleukin-8 (IL-8) and tumour necrosis factor (TNF-alpha) levels and continuous monitoring of arterial blood gases in the intensive care unit (ICU). The analysis of total circulating white blood cells (WBCs)...Continue Reading

References

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Citations

Jan 24, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Oliver WarrenThanos Athanasiou
Dec 3, 2010·Interactive Cardiovascular and Thoracic Surgery·Anna Grace LobergJohn Dark
Jul 2, 2011·The Annals of Thoracic Surgery·Francesco OnoratiAlessandro Mazzucco
Jul 21, 2010·The American Journal of Cardiology·Aslan T Turer, Joseph A Hill
Jul 31, 2007·Heart, Lung & Circulation·Oliver WarrenThanos Athanasiou
Apr 10, 2004·Journal of Cardiothoracic and Vascular Anesthesia·Biao DaiC David Mazer
Aug 2, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Oliver WarrenThanos Athanasiou
Sep 22, 2001·Perfusion·S J Morris
Aug 2, 2013·The Cochrane Database of Systematic Reviews·Sally SpencerEspeed Khoshbin
Jan 22, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Oliver J WarrenThanos Athanasiou
May 15, 2002·Perfusion·George Asimakopoulos

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