Systemic lidocaine decreased the perioperative opioid analgesic requirements but failed to reduce discharge time after ambulatory surgery

Anesthesia and Analgesia
Allannah McKayDanja S Groves

Abstract

In this randomized, blinded, placebo-controlled trial, we evaluated whether systemic lidocaine would reduce pain and time to discharge in ambulatory surgery patients. Sixty-seven patients were enrolled to receive lidocaine or saline infusion perioperatively. Length of postanesthesia care unit (PACU) stay did not differ between groups. Intraoperative opioid use was significantly less in the lidocaine group, both in the PACU and during the total study period but not after discharge. In the PACU, patients in the lidocaine group reported less pain (visual analog scale score 3.1 +/- 2.04 vs 4.5 +/- 2.9; P = 0.043). There were no differences in postoperative nausea and vomiting. Perioperative systemic lidocaine significantly reduces opioid requirements in the ambulatory setting without affecting time to discharge.

Associated Clinical Trials

Nov 30, 2010·Gildasio De Oliveira, Gildasio De Oliveira

References

Sep 2, 2000·Anesthesiology·M W Hollmann, M E Durieux
May 8, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Shaheen ShaikhMark Bernstein
Feb 16, 2006·Statistics in Medicine·Yea-Hung Chen, Xiao-Hua Zhou
Oct 11, 2008·The British Journal of Surgery·E MarretF Bonnet

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Citations

Nov 10, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Louise VigneaultDean A Fergusson
Feb 24, 2011·British Journal of Anaesthesia·E-H LeeI-C Choi
Jul 1, 2011·Journal of Medical Case Reports·Hassan SoleimanpourRobab Mehdizadeh Esfanjani
Sep 24, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Chryssoula StaikouEriphili Argyra
Jan 25, 2011·Expert Opinion on Pharmacotherapy·Frances Lui, Kwok-Fu Jacobus Ng
Dec 17, 2014·Revista brasileira de anestesiologia·Tania Cursino de Menezes CouceiroMarcelo Moraes Valença
May 1, 2015·Brazilian Journal of Anesthesiology·Tania Cursino de Menezes CouceiroMarcelo Moraes Valença
Feb 26, 2016·Pain Practice : the Official Journal of World Institute of Pain·Yuan-Ching ChangShih-Ping Cheng
Jan 24, 2017·Anesthesiology·Lauren K Dunn, Marcel E Durieux
Apr 25, 2014·Acta Cirúrgica Brasileira·Isabela Picolo Guimarães AlvesRenata Navarro Cassu
Jul 18, 2015·The Cochrane Database of Systematic Reviews·Peter KrankeStephanie Weibel
Jun 5, 2018·The Cochrane Database of Systematic Reviews·Stephanie WeibelPeter Kranke
Nov 20, 2009·Anesthesia and Analgesia·Christopher L Wu, Spencer S Liu
Sep 3, 2010·Current Opinion in Anaesthesiology·Pamela E Macintyre, Suellen M Walker
Sep 11, 2010·Current Opinion in Anaesthesiology·Anil Gupta
Dec 14, 2012·Expert Review of Neurotherapeutics·Mario De Pinto, Alex Cahana
Oct 1, 2019·Current Opinion in Anaesthesiology·Philippe RichebéJulien Raft
Feb 20, 2016·Anesthesia and Analgesia·Jeffrey A Klein, Daniel R Jeske
Jan 12, 2019·Anesthesia and Analgesia·Melissa J AsselBrett A Simon
May 16, 2012·Anesthesia and Analgesia·Gildasio S De OliveiraRobert J McCarthy
May 31, 2014·Current Opinion in Anaesthesiology·Peter Brinkrolf, Klaus Hahnenkamp
May 10, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Eben J ClattenburgAndrew A Herring
Aug 18, 2018·Drugs·Marc BeaussierLuc Mercadal
Feb 13, 2018·The Libyan Journal of Medicine·Mohamed Said NakhliWalid Naija
Jul 1, 2010·Expert Opinion on Pharmacotherapy·Jørgen B DahlHenrik Kehlet
Aug 18, 2020·Journal of the American College of Surgeons·Q Lina HuChristine Laronga
Nov 5, 2021·The American Surgeon·Sarah KingBrian Daley
Nov 6, 2010·Current Opinion in Anaesthesiology
Nov 23, 2016·Journal of Clinical Anesthesia·Michele Purper OrtizMiriam Seligman Menezes

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