Systemic lupus erythematosus--activity and outcome

Zeitschrift für Rheumatologie
M Aringer, J Smolen

Abstract

Both clinically and scientifically, the variable organ manifestations of systemic lupus erythematosus (SLE) pose a particular challenge to rheumatologists. Validated scores for disease activity (BILAG, ECLAM, SIS, SLAM, SLEDAI), damage (SLICC/ACR damage index) and health-related quality of life (MOS SF-36) have been successfully used for years. New therapies, however, need to show improvement on outcome parameters for defined organ systems--and these are mostly ill-defined. For proliferative lupus nephritis, well designed studies have been available for years. However, these use very severe outcome parameters (renal failure, death), and therefore take at least 5 years for definitive results. Of the surrogate markers which were devised, none has proven reliable for determining outcome. The combination of shorter studies for defining hopeful strategies followed by long definitive studies, appears to be the best option at present.

References

Sep 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L A HebertJ B Peter
Mar 20, 1998·Arthritis and Rheumatism·M AringerW B Graninger
Jan 12, 1999·Lupus·D T Boumpas, J E Balow
Nov 24, 1999·Lupus·J P BuyonM Khamashta
Oct 18, 2001·Current Opinion in Rheumatology·J Trager, M M Ward
Mar 5, 2004·The New England Journal of Medicine·Gabriel ContrerasDavid Roth
Mar 5, 2004·The New England Journal of Medicine·James E Balow, Howard A Austin
Jul 13, 2004·Arthritis and Rheumatism·Gabor G IlleiPeter E Lipsky
Nov 6, 2004·Arthritis and Rheumatism·UNKNOWN American College of Rheumatology Ad Hoc Committee on Systemic Lupus Erythematosus Response Criteria
Nov 25, 2005·The New England Journal of Medicine·Ellen M GinzlerGerald B Appel

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Citations

Aug 10, 2010·Lupus·J Albrecht, V P Werth
Mar 1, 2014·Zeitschrift für Rheumatologie·M Aringer, M Schneider

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