PMID: 11604598Oct 18, 2001Paper

Systemic lupus erythematosus and antiphospholipid syndrome in children and adolescents

Current Opinion in Rheumatology
T LeeC Sandborg

Abstract

Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) can be associated with significant morbidity in children and adolescents. Renal involvement in SLE appears to be more severe and more frequent in the pediatric age group, with the major predictors for poor outcome being the severity of histopathologic lesions, severity of renal impairment at diagnosis, and hypertension. In addition to currently recognized cardiovascular and pulmonary involvement, accelerated atherosclerosis is of increasing concern in young individuals with SLE, because of both disease effects and medication usage. Neuropsychiatric SLE seen in childhood ranges from subtle cognitive dysfunction to severe central nervous system involvement; however, there is controversy over the value of different diagnostic studies. APS in children may be associated with SLE, idiopathic, or associated with viral infections. Systemic anticoagulation is recommended for patients with thrombotic events, but long-term management has not been well studied in children.

References

Sep 1, 1991·Annals of the Rheumatic Diseases·R CaporaliA Martini
Jun 1, 1990·Annals of the Rheumatic Diseases·A Kraus, G Guerra-Bautista
Jun 1, 1990·Annals of the Rheumatic Diseases·C D Rose, D P Goldsmith
Jul 1, 1988·Arthritis and Rheumatism·N T IlowiteM S Jacobson
Sep 1, 1988·Acta paediatrica Scandinavica·P PelkonenO Vaarala
Jun 1, 1986·The Journal of Nervous and Mental Disease·R M CarbotteJ A Denburg
Oct 29, 1986·Biochimica Et Biophysica Acta·J NimpfR F Zwaal
May 1, 1995·The Journal of Pediatrics·Y UzielE D Silverman
Apr 1, 1994·Archives of Pediatrics & Adolescent Medicine·A RavelliA Martini
May 1, 1993·British Journal of Rheumatology·L V Avioli
Oct 1, 1995·Pediatric Neurology·M I SteinlinE D Silverman
Oct 1, 1995·Pediatric Neurology·S ParikhY Kim
Feb 21, 1998·The Journal of Pediatrics·M GazarianE D Silverman
Mar 5, 1999·Seminars in Thrombosis and Hemostasis·M J Manco-Johnson
Apr 24, 1999·Journal of the American Society of Nephrology : JASN·J S Cameron
Dec 22, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H HatayaM Awazu
Apr 6, 2000·QJM : Monthly Journal of the Association of Physicians·F B KarassaH M Moutsopoulos
Aug 16, 2000·Arthritis and Rheumatism·A Zonana-NacachM Petri
Sep 15, 2000·Clinics in Perinatology·C S Edstrom, R D Christensen
Oct 24, 2000·International Journal of Clinical & Laboratory Research·A VerrottiF Chiarelli

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Citations

Sep 15, 2005·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·K GenschA Kuhn
Feb 11, 2005·Rheumatology International·Simone AppenzellerLilian T L Costallat
Apr 21, 2006·Rheumatology International·Tamás ConstantinGábor Kovács
Feb 6, 2004·The Journal of Thoracic and Cardiovascular Surgery·Yackov BerkunYaakov Naparstek
Dec 24, 2011·La Presse médicale·Alexandre Karras
Oct 12, 2013·Néphrologie & thérapeutique·Manon DekeyserDenis Wahl
Jun 1, 2005·Rheumatic Diseases Clinics of North America·Carl A LaskinKaren A Spitzer
Nov 14, 2002·La Revue de médecine interne·D Le Thi HuongJ C Piette
Jul 27, 2010·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M Fischbach
Aug 9, 2008·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Jian-Ling TaoXue-Wang Li
Aug 18, 2004·Current Opinion in Rheumatology·Dorothee StichwehVirginia Pascual
Oct 27, 2009·Pediatric Rheumatology Online Journal·Tova RonisKaren N Watanabe Duffy
Aug 17, 2005·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·G FallerD Hahn
Nov 6, 2004·Current Rheumatology Reports·Laura E Schanberg, Christy Sandborg
Sep 10, 2002·Current Rheumatology Reports·Ana I Quintero-Del-Rio
Aug 2, 2006·Rheumatic Diseases Clinics of North America·Rolando Cimaz, Elodie Descloux
May 25, 2006·Journal of the American Academy of Nurse Practitioners·Tiwaporn PongmarutaniSally K Miller
Jul 20, 2007·Nephrology·Wasiu A OlowuIdowu O Senbanjo
Feb 24, 2007·Autoimmunity Reviews·Eyal Muscal, Barry L Myones
Jun 17, 2015·Biomarkers in Medicine·Tamar B RubinsteinBeatrice Goilav
Sep 13, 2016·Expert Review of Hematology·Pier Luigi MeroniIrene Pontikaki
May 28, 2004·Journal of Child Neurology·David HsuJin S Hahn
Dec 2, 2006·Arthritis and Rheumatism·Y BerkunG Kenet
Feb 29, 2008·Yonsei Medical Journal·Jieun Choi, Sookyong Koh
Jul 19, 2016·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Amulya A Nageswara RaoVilmarie Rodriguez
Sep 30, 2008·International Journal of Audiology·Charlotte Agrup
May 15, 2020·Current Rheumatology Reports·Ummusen Kaya Akca, Nuray Aktay Ayaz
Feb 13, 2003·Pediatric Clinics of North America·Carolyn Hoppe, Alison Matsunaga

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.