Systemic Lupus Erythematosus and Antiphospholipid Antibody Syndrome

Clinics in Chest Medicine
Maria KokosiSangita Agarwal

Abstract

Systemic lupus erythematosus (SLE) is a systemic inflammatory disease, characterized by an antibody response to nucleic antigens and involvement of any organ system. Pulmonary manifestations are frequent and include pleuritis, acute lupus pneumonitis, chronic interstitial lung disease, alveolar hemorrhage, shrinking lung syndrome, airway disease, pulmonary hypertension (PH), and thromboembolic disease. The antiphospholipid antibody syndrome (APLAS) is a systemic autoimmune disorder where different prothrombotic factors interact to induce arterial and venous thrombosis. The most common pulmonary manifestations are pulmonary thromboembolism and PH. This review will focus on the clinical presentation, diagnosis, and management of the SLE- and APLAS-associated pulmonary conditions.

References

Dec 1, 1992·Seminars in Arthritis and Rheumatism·A D TeitelS A Paget
Dec 15, 1992·Annals of Internal Medicine·K S GinsburgM J Stampfer
Jun 1, 1991·Annals of Internal Medicine·S B AbramsonR M Goldring
Aug 1, 1990·Seminars in Arthritis and Rheumatism·L WeinribF P Quismorio
Feb 1, 1996·AJR. American Journal of Roentgenology·H M FenlonE Breatnach
May 1, 1997·Rheumatic Diseases Clinics of North America·C A Langford, C Van Waes
Jan 20, 2000·Thorax·M P Keane, J P Lynch
Feb 7, 2002·Annals of the Rheumatic Diseases·G EspinosaR A Asherson
Apr 16, 2002·Arthritis and Rheumatism·Ricard CerveraUNKNOWN Euro-Phospholipid Project Group
May 14, 2004·Annals of the Rheumatic Diseases·G EspinosaR A Asherson
Jun 22, 2005·Thrombosis and Haemostasis·Vittorio PengoSabino Iliceto
Jun 23, 2006·The New England Journal of Medicine·Donald P TashkinUNKNOWN Scleroderma Lung Study Research Group
Jul 27, 2006·Arthritis and Rheumatism·Silvia BucciarelliUNKNOWN European Forum on Antiphospholipid Antibodies
Aug 1, 2007·Arthritis and Rheumatism·Brent W KinderLindsey A Criswell
Sep 4, 2007·Seminars in Respiratory and Critical Care Medicine·Beatrice Memet, Ellen M Ginzler
May 15, 2008·Respiration; International Review of Thoracic Diseases·Demosthenes BourosArgyris Tzouvelekis
Sep 20, 2008·Annals of the Rheumatic Diseases·R CerveraUNKNOWN Euro-Phospholipid Project Group (European Forum on Antiphospholipid Antibodies)
Dec 20, 2008·Journal of the American College of Cardiology·Xavier JaïsUNKNOWN Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension Study Group
Aug 10, 2010·Clinics in Chest Medicine·Diane L Kamen, Charlie Strange
Aug 10, 2010·Clinics in Chest Medicine·H James Ford, Robert A S Roubey
Dec 7, 2010·The New England Journal of Medicine·Rupert BauersachsSebastian Schellong
Dec 2, 2011·The New England Journal of Medicine·George C Tsokos
Feb 4, 2012·Respiration; International Review of Thoracic Diseases·Elisabeth LangenskiöldRomain Lazor
Jun 20, 2013·Autoimmunity Reviews·Horacio BermanUNKNOWN Catastrophic Antiphospholipid Syndrome (CAPS) Registry Project Group (European Forum on Antiphospholipid Antibodies)
Jul 3, 2013·The New England Journal of Medicine·Giancarlo AgnelliUNKNOWN AMPLIFY Investigators
Jul 26, 2013·The New England Journal of Medicine·Hossein-Ardeschir GhofraniUNKNOWN CHEST-1 Study Group
Aug 2, 2013·Journal of Thrombosis and Haemostasis : JTH·A Schmidt-TanguyC Belizna
Nov 19, 2013·Best Practice & Research. Clinical Rheumatology·Benjamin E SchreiberJ Gerry Coghlan
Dec 21, 2013·Journal of the American College of Cardiology·Gerald SimonneauRogiero Souza
Mar 29, 2014·Seminars in Respiratory and Critical Care Medicine·Shikha Mittoo, Charlene D Fell
Nov 20, 2014·Rheumatology·Ben Mulhearn, Ian N Bruce
Nov 25, 2014·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Nattawan PalavutitotaiWanruchada Katchamart

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Seminars in Respiratory and Critical Care Medicine
Shikha Mittoo, Charlene D Fell
Current Rheumatology Reviews
Konstantinos Tselios, Murray B Urowitz
Pneumonologia i alergologia polska
Małgorzata H StarczewskaMonika Szturmowicz
Rheumatic Diseases Clinics of North America
J B OrensJ P Lynch
Best Practice & Research. Clinical Rheumatology
José María Pego-ReigosaD A Isenberg
© 2021 Meta ULC. All rights reserved