Systemic lupus erythematosus and malignancies risk

Journal of Cancer Research and Clinical Oncology
Song MaoJianhua Zhang

Abstract

To evaluate the risk of site-specific and overall malignancies after SLE and explore the potential influencing factors. We searched electronic databases for articles that assessed the risk of malignancies after SLE through February 2015. We extracted the incidence rates (IRs) and corresponding 95 % confidence intervals (CIs). We used random effects models to calculate the pooled IRs and assessed the impact of study designs, region, gender, age and duration of follow-up. Eighteen studies were included, giving a pooled IR of 1.44 (95 % CI 1.23-1.69). Europeans, Americans and Asians showed a IR of 1.56 (95 % CI 1.07-2.28), 1.18 (95 % CI 1.01-1.39) and 1.62 (95 % CI 1.38-1.89), respectively. Males and females (eight studies) demonstrated a IR of 1.34 (95 % CI 1.07-1.67) and 1.51 (95 % CI 1.20-1.90), respectively. Prospective and retrospective studies showed a IR of 1.55 (95 % CI 0.97-2.47) and 1.44 (95 % CI 1.21-1.73), respectively. An increment of 10 years of age conferred a decrease in IR of 0.6. An increment of 5 years of SLE duration conferred a decrease in IR of 2.5. An increased IR of malignancies was observed in NHL, vagina/vulva, hematology, head/neck, leukemia, thyroid, liver/gallbladder, kidney, anal, cervix, esophagus, l...Continue Reading

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Citations

Jun 9, 2016·Journal of Toxicology and Environmental Health. Part a·Ji-Hua NieJian Tong
Jul 10, 2018·Current Opinion in Rheumatology·Marco Lopez Velazquez, Kristin B Highland
Sep 6, 2018·Expert Review of Clinical Immunology·Alexandra LadouceurAnn E Clarke
Oct 20, 2018·Internal Medicine·Mayu YagitaMasaaki Fujita
Jul 5, 2019·Clinical Rheumatology·Min-Seok SeoJae-Yong Shim
Dec 12, 2017·Best Practice & Research. Clinical Rheumatology·May Y ChoiAnn E Clarke

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