Systemic lupus erythematosus: clinical manifestations and immunological parameters in 194 patients. Subgroup classification of SLE

Clinical Rheumatology
J AntolinP Jimenez

Abstract

We analysed the prevalence of clinical manifestations and immunological parameters in 194 patients with SLE and classified them in subgroups according to age at onset, gender and type of antibodies: we detected significant differences in the various subgroups. In SLE that initiated before the age of 20 years, the most frequent manifestation at onset was malar rash (25% vs 14%). During the course of the disease, this group had a greater prevalence of malar rash (70% vs 45%), mouth ulcers (48% vs 29%), and convulsions or psychosis (35% vs. 17%). In SLE that initiated late in life (after 50 years) malar rash was less frequent at onset and during subsequent evolution of the disease (27% vs 45%). The existence of ANA, and elevated values of anti-dsDNA, anti-ENA and antiphospholipid antibodies also differentiated the SLE subgroups with clinical significance.

References

May 1, 1979·The American Journal of Medicine·S B BakerJ A Mills
Jan 1, 1978·The American Journal of Medicine·W J Fessel
Aug 1, 1978·Annals of the Rheumatic Diseases·A GaudreauA P Peltier
Jan 1, 1977·Godis̆en Zbornik Na Medicinskiot Fakultet Vo Skopje·M PolenakovićL Grcevska
Feb 1, 1979·Journal of the American Geriatrics Society·J DimantD Kaplan
Oct 1, 1975·Annals of the Rheumatic Diseases·M K AdlerN J Siegel
Jan 1, 1992·Annals of the Rheumatic Diseases·C K Ting, K H Hsieh
Jul 1, 1986·American Journal of Hematology·L R Espinoza, R C Hartmann
Jan 1, 1988·Clinical and Laboratory Haematology·B JudeA Cosson
Feb 1, 1988·British Journal of Rheumatology·P J MaddisonR P Skinner
Jan 1, 1987·Annals of the Rheumatic Diseases·A E GharaviG R Hughes
Jul 1, 1985·American Journal of Hematology·D A GastineauE J Bowie
Nov 1, 1972·Archives of Internal Medicine·B S FoadA B Kirsner
Nov 1, 1972·California Medicine
Sep 1, 1983·Medicine·M H MillerD W Killinger
Oct 15, 1983·British Medical Journal·G R Hughes
Oct 1, 1981·Arthritis and Rheumatism·H A WilsonJ B Winfield
Feb 1, 1982·International Journal of Radiation Oncology, Biology, Physics·H D ThamesG H Fletcher
Oct 1, 1982·Archives of Internal Medicine·R D InmanM D Lockshin
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Jan 1, 1993·Nihon rinsho. Japanese journal of clinical medicine·K NagaokaS Ozaki

❮ Previous
Next ❯

Citations

Oct 12, 2007·Modern Rheumatology·Ken YamajiYoshinari Takasaki
Jun 17, 2004·Nihon rinsho. Japanese journal of clinical medicine·Masanori Funauchi, Toshiaki Yamagata
Jun 20, 2003·American Journal of Clinical Dermatology·Paolo FabbriMarzia Caproni
Jan 24, 2012·Drugs & Aging·Laurent ArnaudZahir Amoura
Mar 15, 2016·Seminars in Arthritis and Rheumatism·Jennifer L MedlinChristie M Bartels
Jun 4, 2002·Best Practice & Research. Clinical Rheumatology·David Hermosillo-Romo, Robin L Brey
Apr 3, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B L LiphausA C Goldberg
Dec 17, 2014·Lupus·L J CatoggioUNKNOWN Grupo Latino Americano De Estudio del Lupus (GLADEL)
Dec 17, 2009·The Journal of Rheumatology·Sheliza LalaniUNKNOWN Members of CaNIOS/1000 Faces of Lupus

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.