Systemic lupus erythematosus in a multiethnic US cohort. XXXIII. Clinical [corrected] features, course, and outcome in patients with late-onset disease

Arthritis and Rheumatism
Ana M BertoliLUMINA Study Group

Abstract

To examine the clinical differences and the type and extent of organ damage in late- versus early-onset systemic lupus erythematosus (SLE). A nested case-control study was performed in the context of LUMINA (LUpus in MInorities, NAture versus nurture), a large, longitudinal, multiethnic cohort. Patients who developed SLE at or after the age of 50 years were considered cases. Two controls (patients who developed SLE at age < or = 49 years) per case, matched for sex and disease duration, were randomly chosen. Selected baseline socioeconomic/demographic, behavioral, and psychological features, self-reported quality of life, and cumulative clinical data (clinical manifestations, laboratory data, disease activity, damage, and mortality) were compared between cases and controls. Multivariable analyses with late-onset lupus, damage accrual, and mortality as dependent variables were then performed. Two hundred seventeen patients were studied. Of them, 73 were cases. Cases were more likely to have neurologic involvement, arterial thrombotic events, osteoporosis, and hypertriglyceridemia, while renal involvement and anti-Sm antibodies were less frequent. Disease activity at baseline was lower among cases. Cases also exhibited more cardio...Continue Reading

References

May 1, 1979·The American Journal of Medicine·S B BakerJ A Mills
Feb 1, 1976·The American Journal of Medicine·M B UrowitzM A Ogryzlo
Oct 1, 1991·Annals of the Rheumatic Diseases·J FontM Ingelmo
Oct 1, 1989·Arthritis and Rheumatism·M M Ward, R P Polisson
May 1, 1984·Nihon rinsho. Japanese journal of clinical medicine·T Ofuji
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Sep 1, 1995·Arthritis and Rheumatism·D J McCartyC K Kwoh
Jan 1, 1993·Nihon rinsho. Japanese journal of clinical medicine·K NagaokaS Ozaki
Dec 1, 1996·Seminars in Arthritis and Rheumatism·A KatzP Langevitz
Nov 3, 1998·Annals of the Rheumatic Diseases·C T HoR W Wong
Jan 5, 2002·Arthritis and Rheumatism·G S AlarcónUNKNOWN LUMINA Study Group. Lupus in Minority Populations, Nature versus Nurture
Dec 11, 2002·Best Practice & Research. Clinical Rheumatology·Michelle Petri
Feb 25, 2003·Journal of Experimental Botany·Fiona R HayFiona J Wilson
Aug 19, 2003·Rheumatology·G S AlarcónUNKNOWN LUMINA Study Group

❮ Previous
Next ❯

Citations

Sep 4, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B MezukS H Golden
Dec 30, 2006·Rheumatology International·Melissa PadovanFrancesco Trotta
Jan 25, 2011·Rheumatology International·Achouak AchourIbtissem Ghedira
Mar 22, 2013·Clinical Rheumatology·Aleksandra Tomic-LucicMirjana Veselinovic
Oct 12, 2007·Modern Rheumatology·Ken YamajiYoshinari Takasaki
Jan 24, 2012·Drugs & Aging·Laurent ArnaudZahir Amoura
Nov 26, 2013·Reumatología clinica·Luis Fernando Pinto PeñarandaCarlos Jaime Velásquez Franco
Jan 15, 2014·Autoimmunity Reviews·R CerveraI Boucot
Mar 6, 2012·Revista española de geriatría y gerontología·Xavier BoschAlfonso López-Soto
Jan 13, 2009·Seminars in Arthritis and Rheumatism·Guillermo J Pons-EstelGlinda S Cooper
Apr 15, 2010·Arthritis Care & Research·Karen H CostenbaderFrederick Wolfe
Apr 25, 2015·Thrombosis Journal·Mario BazzanFabio Marletto
Apr 1, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Luca MoroniPier Luigi Meroni
May 5, 2017·Expert Review of Clinical Immunology·Guillermo J Pons-EstelGraciela S Alarcón
May 5, 2017·Expert Review of Clinical Immunology·Luis Alonso González, Graciela S Alarcón
Dec 17, 2014·Lupus·L J CatoggioUNKNOWN Grupo Latino Americano De Estudio del Lupus (GLADEL)
Oct 15, 2008·Lupus·Graciela S Alarcón
Nov 17, 2010·The Journal of Rheumatology·Sasha BernatskyUNKNOWN Canadian Network for Improved Outcomes in Systemic Lupus Erythematosus (CaNIOS)
Dec 17, 2009·The Journal of Rheumatology·Sheliza LalaniUNKNOWN Members of CaNIOS/1000 Faces of Lupus
Jul 17, 2018·The Journal of Rheumatology·Amanda M EudyMichelle Petri
Jul 1, 2008·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Sonosuke YukawaNorioki Tsuboi
Feb 27, 2016·The European Respiratory Journal·Paolo SpagnoloVincent Cottin
May 23, 2012·Expert Review of Clinical Immunology·Ignacio Villa-Blanco, Jaime Calvo-Alén
Aug 30, 2019·Current Opinion in Rheumatology·Wendy Marder
Aug 6, 2019·Frontiers in Immunology·Rustem I LitvinovJohn W Weisel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.