Systemic Lupus Erythematosus, Sjögren Syndrome, and Mixed Connective Tissue Disease in Children and Adolescents

Pediatric Clinics of North America
Stacey E Tarvin, Kathleen M O'Neil

Abstract

Juvenile systemic lupus erythematosus (jSLE), mixed connective tissue disease (jMCTD), and Sjögren syndrome (jSS) are systemic autoimmune and inflammatory disorders with distinct patterns of organ involvement. All are characterized by autoantibody formation, with antinuclear (ANA) and anti-double-stranded DNA common in jSLE, ANA with high-titer ribonucleoprotein antibody in jMCTD, and Sjögren syndrome A and Sjögren syndrome B antibodies + ANA in jSS. Recognition, monitoring, and management for primary care providers are discussed, focusing on the role of primary physicians in recognizing and helping maintain optimal health in children with these potentially life-threatening diseases.

Citations

May 31, 2019·Current Opinion in Rheumatology·Amandine Charras, Christian M Hedrich
May 12, 2019·Indian Journal of Pediatrics·Bipin JosePreethy Harrison
Jun 21, 2020·Current Cardiology Reports·Bogna Grygiel-GórniakMichal Klokner
Aug 21, 2020·International Journal of Rheumatic Diseases·Qian Wang, Sheng-Ming Dai
Feb 20, 2019·Pediatric Rheumatology Online Journal·Natoshia R CunninghamSusmita Kashikar-Zuck
Oct 4, 2020·Nature Reviews. Rheumatology·Maurizio Cutolo, Rainer H Straub
Jan 4, 2021·European Journal of Pediatrics·Pondtip Jongvilaikasem, Pornpimol Rianthavorn
Mar 7, 2021·Antibodies·Irina A PashninaValeriy A Chereshnev

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