PMID: 9544379Apr 17, 1998Paper

Systemic lupus erythematosus (SLE): changing concepts and challenges for the new millennium

Australian and New Zealand Journal of Medicine
I Rasaratnam, P F Ryan

Abstract

SLE is still the prototype experimental animal and human autoimmune disease. The clinical manifestations are so diverse that some have come to regard it as the incumbent 'luetic heir apparent' of the late 20th century. The aberrations of the immune disturbance have up until now defied clear explanation but have certainly generated a level of academic and research interest far greater than the frequency of the disease would initially suggest. The clear understanding of the immune derangements in SLE will probably lead to the understanding of the core mechanisms of the immune system and thus to better ways of its specific manipulation in the management of many other conditions including cancer. Research currently being undertaken on the mechanisms of control of immunologically mediated inflammation and the possible use of immunogenetic therapy in the treatment of various forms of SLE will hopefully further improve SLE related morbidity and mortality.

Citations

Oct 20, 1998·Australian and New Zealand Journal of Medicine·B A Pussell
Oct 25, 2016·Autoimmunity Reviews·Dana Ben-Ami ShorHoward Amital
Jul 5, 2018·Korean journal of family medicine·Mahnaz SandoughiFarzaneh Barzkar

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