PMID: 9643312Jun 27, 1998Paper

Systemic lupus erythematosus VII: frequency and impact of secondary Sjøgren's syndrome

Lupus
J C Nossent, A J Swaak

Abstract

The prognosis of patients with systemic lupus erythematosus (SLE) largely depends on the severity of cumulative organ damage during the course of the disease. While Sjøgren's syndrome (SS) predominantly affects exocrine glands, a considerable number of patients develop visceral organ damage. Thus, the occurrence of a secondary SS (2(o)SS) in SLE patients, may result in more extensive organ damage and thereby adversely affect prognosis. 138 patients meeting the 1982 American College of Rheumatology (ACR) classification criteria for SLE were prospectively studied over a mean period of ninety months. 2(o)SS was diagnosed according to the 1993 European Study Group criteria and complication rates and prognosis were compared between patients with and without SS. 27 patients (19%) developed SS after a mean period of 48 months. There was a gradual increase in SS prevalence over time after SLE-onset. 2(o)SS patients were older (mean age 41 vs 35 years, P = 0.03), had less renal disease (19% vs 38%, P = 0.04), more thrombocytopenia (26% vs 9%, P = 0.05) and similar serological profiles (including anti-SSa) as patients without SS. Overall mortality was lower in patients with SS (4% vs 13.5%, P = 0.01), while lifetable analysis showed impr...Continue Reading

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Citations

Apr 10, 2009·Zeitschrift für Rheumatologie·E FeistA Dankof
Jan 22, 2003·Alimentary Pharmacology & Therapeutics·J-C LuoS-D Lee
Apr 19, 2013·Rheumatology·Gabriela Hernández-MolinaJorge Sánchez-Guerrero
Dec 14, 2011·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Qingping YaoXiaofeng Wang
Jul 1, 2008·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Naomi IwataShumpei Yokota
Mar 1, 2007·Expert Review of Clinical Immunology·Manuel Ramos-Casals, Pilar Brito-Zerón
Sep 29, 2011·The Journal of Sexual Medicine·Jui-Cheng TsengBang-Ping Jiann
Jan 15, 2008·Autoimmunity Reviews·Chiara BaldiniStefano Bombardieri
Jan 15, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Toshiharu HayashiKeiko Hasegawa
Sep 26, 2006·Seminars in Arthritis and Rheumatism·Manuel Ramos-CasalsJosep Font
Jun 30, 2012·Autoimmunity Reviews·Luca IaccarinoAndrea Doria
Jul 20, 2016·Rheumatic Diseases Clinics of North America·Juan-Manuel AnayaJuan Camilo Sarmiento-Monroy
Mar 7, 2014·Lupus·M FangthamM A Petri
Mar 3, 2010·The Journal of Rheumatology·Gabriela Hernández-MolinaJorge Sánchez-Guerrero
Apr 3, 2010·The Journal of Rheumatology·Alan N BaerMichelle Petri
Jun 20, 2008·Virchows Archiv : an International Journal of Pathology·Toshiharu HayashiKeiko Hasegawa
Sep 15, 2000·Rheumatology·P E GeorgiouA A Drosos
Dec 15, 2018·International Journal of Rheumatic Diseases·Agata MatusiewiczMarzena Olesińska
Sep 17, 2019·The Journal of Rheumatology·Guillermo RuachoElisabet Svenungsson
Nov 25, 2020·Journal of Korean Medical Science·Hyoungyoung KimYoon Kyoung Sung
Jul 22, 2021·Zeitschrift für Rheumatologie·Cristiana Sieiro SantosElvira Díez Alvarez

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