Systemic lupus erythematosus with disease onset after age 65

La Revue de médecine interne
S GaujardH Rousset

Abstract

Systemic lupus erythematosus with disease-onset in the elderly has rarely been studied (only one report about 21 patients with disease onset at 65 and older). Is the management of this pathology modified in this population? Seventeen hospitalised cases of lupus patients with disease onset at 65 or older are retrospectively reported between 1988 and 2000. The results are compared with those of younger subjects. The female to male ratio is 1.83. Mean age at disease onset is 71.9 +/- 3.5 years. Mean duration of follow-up is 3.5 +/- 2.4 years. Main initial symptoms are: deterioration of general status (41%), arthritis (35%), cutaneous manifestations (35%), thrombo-embolism (24%) and pleuritis (18%). Malar rash is uncommon (12%). Nephropathy is never a revealing symptom and is rarely serious during the disease's evolution. Like in neurologic manifestations, the etiology has to be discussed in relation to associated co-morbidities. Concerning haematologic features, lymphopenia is found in 82% of the cases with a questionable specificity. Antinuclear antibodies are constant, anti-dsDNA antibodies are found in 82% of the cases, antibodies to extractable nuclear antigens in 50%, and anticoagulant circulating activity in 59%. Prognosis i...Continue Reading

Citations

Jan 24, 2012·Drugs & Aging·Laurent ArnaudZahir Amoura
Feb 7, 2013·International Archives of Medicine·Sonia HammamiHamouda Saffar
Dec 30, 2006·Rheumatology International·Melissa PadovanFrancesco Trotta
Jan 25, 2011·Rheumatology International·Achouak AchourIbtissem Ghedira

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