PMID: 28502135May 16, 2017Paper

Systemic Lupus Erythmatosus is Associated with Disturbed Cytokine Milieu and Increased TNF-Related Apoptosis-Induced Ligand Levels

The Egyptian Journal of Immunology
Amal M Saeed, Mysara M Mogahed

Abstract

Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is cytotoxic to a wide variety of transformed cells, but not to most normal cells. This study measures serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and 10 and soluble TRAIL (sTRAIL) in patients with SLE and assesses their relation to severity of the disease. The study included 70 SLE patients and 20 healthy controls. Patients were diagnosed according to criteria proposed by the American Rheumatism Association for classification of SLE and disease activity was scored using the British Isles Lupus Assessment Group (BILAG-2004). All study participants were subjected to estimation of TNF-α, IL-6, IL-10 and sTRAIL using ELISA. Results revealed that mean disease duration was 6.5±1.5 years, mean BILAG score was 18.2±12.1, while 15 patients (21.4%) had quiescent disease. Blood levels of C3 and C4 and leucocytic count showed progressive decrease, while serum C-reactive protein and anti-double strand DNA antibodies levels showed marked increase with increased disease activity. Five patients (7.1%) were neutropenic. Serum levels of sTRAIL and IL-6 were significantly (P>0...Continue Reading

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