Systemic mastocytosis associated with acute myeloid leukemia: case report and implications for disease pathogenesis

The Journal of Allergy and Clinical Immunology
Luis EscribanoAlberto Orfao

Abstract

Mastocytosis may be associated with clonal nonmast cell lineage hematologic diseases, including myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia. Here we present a patient with the simultaneous diagnosis of mastocytosis and an acute myeloid leukemia, M2 subtype in the French-American-British classification, with t(8;21) carrying a population of immature mast cell precursors, and discuss this presentation in the context of a potential pathogenetic cellular link between this leukemia and mastocytosis.

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Citations

Dec 1, 2008·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Rakhee KarHara Prasad Pati
Aug 12, 2009·Journal of Hematopathology·Sheeja T PullarkatRussell K Brynes
Sep 16, 2011·International Journal of Cardiology·Akrivi ManolaPaul D Thompson
Aug 26, 2006·Immunology and Allergy Clinics of North America·Luis EscribanoUNKNOWN Red Española de Mastocitosis
Jun 9, 2007·British Journal of Haematology·Alberto OrfaoUNKNOWN REMA
Jul 17, 2010·Pathology·Catherine Fong, Michael Tong
Jul 9, 2004·The Journal of Allergy and Clinical Immunology·Yoseph A Mekori
May 29, 2013·Hematology/oncology and Stem Cell Therapy·Santhosh SadashivAntonious Christou
Aug 19, 2009·American Journal of Clinical Pathology·Magdalena Czader, Attilio Orazi
Sep 21, 2013·American Journal of Clinical Pathology·Ryan C JohnsonTracy I George

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