PMID: 9652907Jul 4, 1998Paper

Systemic mastocytosis with extensive polypoid lesions in the intestines; successful treatment with interferon-alpha

Internal Medicine
Y TakasakiK Makiyama

Abstract

A 35-year-old female presented in 1989 with hepatosplenomegaly, but no conclusive diagnosis was established. From 1992, she experienced transient episodes of facial flushing and palpitations. Osteosclerotic change was detected radiologically. Colonoscopy revealed massive polypoid lesions. Mast cells were demonstrated in bone marrow smear and imprinted preparations of colon biopsy specimens by toluidine blue staining. Plasma concentrations of histamine and soluble c-kit were elevated. She was successfully treated with interferon-alpha and prednisolone, resulting in the disappearance of histamine-related attacks and a gradual decrease in tumor size. However, the remission was interferon dose dependent. This case was considered as systemic mastocytosis with massive polypoid colon lesions and showed the importance of maintenance therapy with interferon-alpha.

Citations

Jul 31, 2013·The Journal of Allergy and Clinical Immunology·Harry SokolOlivier Hermine
Sep 27, 2012·Hematology/oncology Clinics of North America·Animesh Pardanani
May 31, 2013·American Journal of Hematology·Animesh Pardanani
Mar 29, 2011·American Journal of Hematology·Animesh Pardanani
Feb 18, 2015·American Journal of Hematology·Animesh Pardanani
Jul 18, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·U MickysG De Hertogh
Aug 11, 2010·Neuroscience and Biobehavioral Reviews·David T MarcKelly L Olson
Oct 21, 2016·American Journal of Hematology·Animesh Pardanani
Feb 18, 2010·Inflammatory Bowel Diseases·Harry SokolOlivier Hermine
Dec 4, 2003·Pediatrics International : Official Journal of the Japan Pediatric Society·Hüseyin CaksenMehmet Erol
Apr 12, 2001·The British Journal of Dermatology·K Hartmann, B M Henz
Nov 23, 2007·The Cancer Journal·Animesh Pardanani, Srdan Verstovsek
Mar 14, 2012·American Journal of Hematology·Animesh Pardanani
Oct 21, 2004·American Journal of Hematology·Bryan HennessySrdan Verstovsek
Jul 26, 2000·Hematology/oncology Clinics of North America·R T Jensen
Jul 26, 2000·Hematology/oncology Clinics of North America·A S Worobec

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