Systemic Mastocytosis

Surgical Pathology Clinics
Tracy I George, Hans-Peter Horny

Abstract

An unusual disease, mastocytosis challenges the pathologist with a variety of morphologic appearances and heterogeneous clinical presentations ranging from skin manifestations (pruritus, urticaria, dermatographism) to systemic signs and symptoms indicative of mast cell mediator release, including flushing, hypotension, headache, and anaphylaxis among others. In this article, we focus on recognizing the cytology, histopathology, clinical features, and prognostic implications of systemic mastocytosis, a clonal and neoplastic mast cell proliferation infiltrating extracutaneous organ(s) with or without skin involvement. Diagnostic pitfalls are reviewed with ancillary studies to help unmask the mast cell and exclude morphologic mimics.

References

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Oct 30, 2009·The Journal of Investigative Dermatology·Christine BodemerPatrice Dubreuil

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Citations

Dec 1, 2013·Surgical Pathology Clinics·Ryan C Johnson, Tracy I George
Aug 14, 2012·American Journal of Hematology·Natasha M SavageTracy I George
Jan 18, 2016·The Journal of Allergy and Clinical Immunology·Avanti DesaiDean D Metcalfe

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