Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposure

Environmental Health Perspectives
Timothy R NurkiewiczMatthew A Boegehold

Abstract

The epidemiologic association between pulmonary exposure to ambient particulate matter (PM) and cardiovascular dysfunction is well known, but the systemic mechanisms that drive this effect remain unclear. We have previously shown that acute pulmonary exposure to PM impairs or abolishes endothelium-dependent arteriolar dilation in the rat spinotrapezius muscle. The purpose of this study was to further characterize the effect of pulmonary PM exposure on systemic microvascular function and to identify local inflammatory events that may contribute to these effects. Rats were intratracheally instilled with residual oil fly ash (ROFA) or titanium dioxide at 0.1 or 0.25 mg/rat 24 hr before measurement of pulmonary and systemic microvascular responses. In vivo microscopy of the spinotrapezius muscle was used to study systemic arteriolar responses to intraluminal infusion of the Ca2+ ionophore A23187 or iontophoretic abluminal application of the adrenergic agonist phenylephrine (PHE). Leukocyte rolling and adhesion were quantified in venules paired with the studied arterioles. Histologic techniques were used to assess pulmonary inflammation, characterize the adherence of leukocytes to systemic venules, verify the presence of myeloperoxi...Continue Reading

References

Oct 1, 1996·Journal of the Air & Waste Management Association·J SchwartzL M Neas
Feb 21, 1997·Journal of Toxicology and Environmental Health·K L DreherD L Costa
Nov 28, 1997·American Journal of Respiratory Cell and Molecular Biology·J A DyeK L Dreher
Aug 26, 1998·Toxicological Sciences : an Official Journal of the Society of Toxicology·U P KodavantiD L Costa
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·W C TanJ C Hogg
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·D M LendaM A Boegehold
Nov 15, 2000·Toxicology and Applied Pharmacology·B VeronesiS H Gavett
Dec 15, 2000·The New England Journal of Medicine·J M SametS L Zeger
May 16, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·L Calderón-GarcidueñasR B Devlin
May 26, 2001·The Journal of Biological Chemistry·C ZhangC R White
Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·S F van EedenJ C Hogg
Nov 16, 2001·Toxicology and Applied Pharmacology·T M RiceJ D Paulauskis
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·A NemmarB Nemery
Feb 15, 2002·Journal of Vascular Research·Deborah M Lenda, Matthew A Boegehold
Mar 7, 2002·JAMA : the Journal of the American Medical Association·C Arden PopeGeorge D Thurston
Jun 29, 2002·Science·Jason P EiserichBruce A Freeman
Oct 4, 2002·Environmental Health Perspectives·Joel SchwartzAntonella Zanobetti
Oct 22, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·James M AntoniniRobert W Clarke
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·W G KreylingA Ziesenis
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·Günter OberdörsterChristopher Cox
Apr 5, 2003·Environmental Health Perspectives·Ning LiAndre Nel
Nov 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Atsushi SatoDavid D Gutterman
Dec 19, 2003·Journal of Toxicology and Environmental Health. Part a·Jenny R RobertsJames M Antonini
Jun 3, 2004·Circulation·Robert D BrookUNKNOWN Expert Panel on Population and Prevention Science of the American Heart Association
Jun 17, 2004·JAMA : the Journal of the American Medical Association·Allison A HedleyKatherine M Flegal
Jun 19, 2004·Inhalation Toxicology·Karim BagatéPaul J A Borm
Jun 19, 2004·Inhalation Toxicology·G OberdörsterC Cox
Jul 2, 2004·American Journal of Respiratory and Critical Care Medicine·Frank SchaumannNorbert Krug
Sep 4, 2004·Environmental Health Perspectives·Timothy R NurkiewiczMatthew A Boegehold
Oct 23, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Longkun ZhuPingnian He
Dec 8, 2004·Environmental Health Perspectives·K Murali Krishna RaoVince Castranova
Feb 4, 2005·Journal of Leukocyte Biology·Seymour J Klebanoff
Oct 1, 1996·Journal of the Air & Waste Management Association·Joel SchwartzLucas M Neas

❮ Previous
Next ❯

Citations

Aug 9, 2012·Future Cardiology·Mark R MillerJeremy P Langrish
Jul 19, 2013·BioMed Research International·Abderrahim NemmarErnesto Alfaro-Moreno
Mar 4, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Dovenia S PonnothS Jamal Mustafa
May 2, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Clarke G TankersleyWayne Mitzner
Mar 10, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Timothy R NurkiewiczVincent Castranova
Apr 18, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Matthew J Campen
Jun 24, 2009·Respiratory Research·Jie ChaoNorberto C Gonzalez
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·A J LeBlancT R Nurkiewicz
Sep 4, 2010·American Journal of Respiratory Cell and Molecular Biology·Jie ChaoNorberto C Gonzalez
Sep 28, 2010·Environmental Health Perspectives·Tom W CherngNancy L Kanagy
May 23, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Jie ChaoNorberto C Gonzalez
Dec 4, 2012·International Journal of Molecular Sciences·Phoebe A StapletonTimothy R Nurkiewicz
Mar 8, 2013·PloS One·Jennifer A BorcherdingAlejandro P Comellas
Sep 27, 2007·Reviews on Environmental Health·Robert D Brook
Sep 13, 2015·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Günter OberdörsterPhil Sayre
Aug 27, 2011·Inhalation Toxicology·Paul T CutrufelloGeorgios A Stylianides
Feb 14, 2008·Particle and Fibre Toxicology·Timothy R NurkiewiczVincent Castranova
Apr 9, 2014·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Kirsten KoehlerJohn Volckens
May 27, 2015·PloS One·Akhilesh DubeyDharmendra Chaudhary
Jun 25, 2016·Particle and Fibre Toxicology·Cristhiam Rueda-RomeroErnesto Alfaro-Moreno
May 7, 2013·American Journal of Obstetrics and Gynecology·Phoebe A StapletonTimothy R Nurkiewicz
Mar 16, 2011·Respiratory Physiology & Neurobiology·Jie ChaoNorberto C Gonzalez
May 6, 2008·Toxicology and Applied Pharmacology·Travis L KnucklesMatthew J Campen
May 6, 2008·Toxicology Letters·Elizabeth OesterlingBernhard Hennig
Oct 30, 2007·Journal of Toxicology and Environmental Health. Part a·Katie FinnertyPaul F McDonagh
Sep 16, 2011·Journal of Toxicology and Environmental Health. Part a·Kristine KrajnakVincent Castranova
May 27, 2016·Human & Experimental Toxicology·N LabrancheS Pochet

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage
dissection
PCR

Software Mentioned

Sigmastat

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.