Systemic neosporosis in a dog treated for immune-mediated thrombocytopenia and hemolytic anemia

Veterinary Clinical Pathology
Angie MagañaElizabeth Morales

Abstract

A 4-year-old male Toy Poodle was presented to the Small Animal Veterinary Hospital of the Faculty of Veterinary Medicine of the Autonomous University of Mexico (FMVZ, UNAM) because of depression, lethargy, and hemorrhages involving several areas of the skin and around the eyes. Hematology data and a bone marrow analysis suggested hemolytic anemia and immune-mediated thrombocytopenia. The dog was treated with prednisone, and after one month the hematology variables improved. However, the dog's clinical condition inexplicably worsened and it was euthanized. On necropsy, there were no relevant findings. However, in histology, multifocal lymphoplasmacytic and histiocytic meningoencephalitis and necrosis, and a protozoan cyst in the cerebellum were identified. In addition, moderate multifocal lymphoplasmacytic and necrotizing pancreatitis, hepatitis, myocarditis, and diffuse lymphoplasmacytic enteritis were observed. Immunohistochemistry of the cerebellum, liver, pancreas, and intestine with a specific antibody against Neospora caninum confirmed the diagnosis of systemic neosporosis. The systemic neosporosis in this dog was most likely caused by reactivation of latent parasites due to prednisone administration during the one month o...Continue Reading

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Citations

Aug 21, 2016·The Onderstepoort Journal of Veterinary Research·Mohsen ArbabiMajid Pirestani
Feb 27, 2019·Journal of Veterinary Internal Medicine·Oliver A GardenBalazs Szladovits
Mar 8, 2019·Journal of Veterinary Internal Medicine·Cynthia R L WebsterPenny J Watson
Mar 14, 2019·Frontiers in Veterinary Science·Rafael Calero-Bernal, Solange M Gennari
Sep 22, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Benjamin CurtisJuan Muñoz Gutiérrez

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