Systemic nitric oxide augmentation leads to a rapid decrease of the bladder outlet resistance in healthy men

European Urology
Michael MüntenerAndré Reitz

Abstract

We examined the immediate effect of a systemic nitric oxide augmentation on the bladder outlet resistance in healthy men. Eleven healthy male volunteers with a mean age of 25.5 yr were included in the study. They were prepared for a standard urodynamic study, and a baseline pressure-flow study was obtained. The subjects were then given 20 mg isosorbide dinitrate sublingually, and after refilling their bladder a second pressure-flow study was done after 20 min. The pressure-flow studies were then compared in regard to the average flow rate, the average detrusor pressure during micturition, and the detrusor pressure at maximum flow rate. One of the subjects was unable to void and had to be excluded from the study. In the remaining 10 men, the mean average flow rate increased from 16.7 ml/s before to 20.2 ml/s after the intake of the NO donor (P=0.013). Concomitantly, the average detrusor pressure during micturition decreased from a mean of 57 to 52 cm H2O (P=0.004) and the mean detrusor pressure at maximum flow rate decreased from 60 to 52 cm H2O (P=0.013). Systemic NO augmentation can lower the functional bladder outlet resistance very rapidly in men. Our results support the concept that the NO-cGMP pathway may be a promising ta...Continue Reading

References

Jun 1, 1995·The Journal of Urology·B C BennettW C de Groat
Mar 1, 1995·Urology·M TakedaH Lepor
Nov 1, 1995·British Journal of Pharmacology·M Takeda, H Lepor
Feb 15, 2000·International Urology and Nephrology·T KlotzU Engelmann
May 23, 2002·World Journal of Urology·Karl-Erik AnderssonK Höfner
Dec 4, 2002·BJU International·K SairamD C Hanbury
Jun 18, 2003·Urology·Mamas A MamasAlison F Brading
Jul 11, 2003·The Journal of Urology·UNKNOWN AUA Practice Guidelines Committee
Mar 31, 2004·Nitric Oxide : Biology and Chemistry·Deepali Pitre Poladia, John Anthony Bauer
Oct 20, 2004·Urology·Anton PonholzerStephan Madersbacher
Jun 11, 2005·The Journal of Urology·Rahman ShiriJuha Koskimäki
Nov 30, 2005·European Urology·Claus G Roehrborn
Jan 13, 2006·Urologia Internationalis·Michael MüntenerBrigitte Schurch

❮ Previous
Next ❯

Citations

Sep 10, 2013·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·X GaméB Malavaud
Dec 8, 2011·The Journal of Sexual Medicine·Xavier GaméBernard Malavaud
Feb 14, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Hitoshi Masuda
Mar 18, 2011·Neurourology and Urodynamics·Fabíola Z MónicaEdson Antunes
Jan 26, 2012·Neurourology and Urodynamics·L A BirderC H Fry
Dec 1, 2010·Einstein·Carlos Arturo Levi D'AnconaEdson Antunes
Apr 20, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Warren G Hill
Mar 14, 2008·International Journal of Immunopathology and Pharmacology·D MinardiG Muzzonigro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.