PMID: 9536926Apr 16, 1998Paper

Systemic nitric oxide synthase inhibition increases insulin sensitivity in man

Clinical Science
R ButlerA D Struthers

Abstract

1. Recent evidence shows that skeletal muscle blood flow is an important determinant of insulin sensitivity and that insulin-mediated vasodilatation is nitric oxide dependent. These results have given rise to the hypothesis that endothelial nitric oxide inhibition may decrease insulin sensitivity in humans. 2. We examined this hypothesis directly by evaluating the effects of systemic nitric oxide synthase inhibition with NG-monomethyl L-arginine (3 mg h-1 kg-1) on whole-body glucose uptake (euglycaemic hyperinsulinaemic clamp) and calf blood flow (bilateral calf venous occlusion plethysmography) in 16 healthy male subjects in a randomized, double-blind, placebo-controlled, crossover study. 3. NG-Monomethyl L-arginine infusion was associated with a pressor effect (119/61 +/- 2/2 compared with 114/58 +/- 2/2 mmHg for placebo; P < 0.001), and a negative chronotropic response (57 +/- 2 compared with 62 +/- 2 beats/min for placebo; P < 0.001). The glucose infusion rate was significantly increased after infusion of NG-monomethyl L-arginine (8.9 +/- 0.9 compared with 7.9 +/- 0.8 mg min-1 kg-1 for placebo; P = 0.002). Whole-body glucose uptake increased during the clamp, with values of 9.4 +/- 0.7 and 10.9 +/- 0.8 mg min-1 kg-1 for pla...Continue Reading

Citations

Dec 23, 2006·Antioxidants & Redox Signaling·Masao KanekiKyungho Chang
Feb 12, 2005·Endocrinology·Chi-Chang JuanLow-Tone Ho
Jan 12, 2001·Physiological Reviews·J S Stamler, G Meissner
Oct 23, 2002·Journal of Applied Physiology·Gunvor Ahlborg, Jonas Lindström
Jan 6, 2005·The Journal of Biological Chemistry·Takashi YasukawaMasao Kaneki

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