Systemic Octreotide Therapy in Prevention of Gastrointestinal Bleeds Related to Arteriovenous Malformations and Obscure Etiology in Atrial Fibrillation

JACC. Clinical Electrophysiology
Venkat VuddandaDhanunjaya Lakkireddy

Abstract

The present study describes the use of octreotide (OCT) in patients with atrial fibrillation (AF) receiving oral anticoagulation (OAC) who have gastrointestinal (GI) bleeding related to arteriovenous malformations (AVMs), as well as its effect on OAC tolerance and subsequent rebleeding. AVMs cause significant GI bleeding, especially in patients with AF who are receiving OAC for stroke prevention. OCT has been shown to minimize recurrent GI bleeds related to AVMs. In a multicenter, observational study, 38 AF patients with contraindications to OAC because of AVM-related GI bleeding were started on 100 μg of subcutaneous OCT twice daily. OAC was resumed in all patients within 48 h. Incidence of recurrent GI bleeds was calculated, and hemoglobin levels were recorded at enrollment and at 3 and 6 months' follow-up. After a median follow-up of 8 months, 36 patients (mean age 69 ± 8.0 years; mean CHA2DS2-VASc score 3 ± 1 and mean HAS-BLED score 3 ± 1) were available for analysis. All were able to successfully resume OAC, and 28 of 36 (78%) remained on OAC at the conclusion of the study, whereas 8 underwent left atrial appendage closure with subsequent OAC discontinuation. No systemic thromboembolic events occurred in follow-up. Of the ...Continue Reading

References

Oct 1, 1993·The Journal of Surgical Research·R BarrieW S Fletcher
Apr 14, 1999·The American Journal of Gastroenterology·F JunqueraJ R Malagelada
Feb 4, 2003·Alimentary Pharmacology & Therapeutics·J GarlandM E Caplin
Jul 14, 2004·European Journal of Endocrinology·Staffan V WelinBarbro K Eriksson
Jun 25, 2005·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·A Atmaca, T Erbas
Mar 22, 2006·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Andrew Szilagyi, Maged P Ghali
Feb 22, 2007·The American Journal of Gastroenterology·Félix JunqueraJuan-Ramón Malagelada
Sep 5, 2007·Alimentary Pharmacology & Therapeutics·G ScaglioneI Sorrentini
Nov 7, 2007·Gastroenterology·Gottumukkala S RajuUNKNOWN American Gastroenterological Association
Feb 27, 2009·European Journal of Gastroenterology & Hepatology·Sian ChisholmJeffrey House
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Oct 22, 2009·Current Medical Research and Opinion·Lowell Anthony, Pamela U Freda
Jun 10, 2010·The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology·Mustafa TuncerUnal Güntekin
Jul 9, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Madhuri AdabalaMichael Gitman
Feb 25, 2011·Medicina intensiva·M Cruz TejedorJ E Guerrero Sanz
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Jun 2, 2012·Heart & Lung : the Journal of Critical Care·Luke Simon Olivera YuhicoRobert Lenox
Oct 11, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Miguel GlatsteinYedidia Bentur
Feb 26, 2013·British Journal of Haematology·Massimo Franchini, Pier Mannuccio Mannucci
Mar 14, 2013·The Annals of Thoracic Surgery·Stephen J ForestDaniel J Goldstein
Jul 4, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Stephen L RennysonRajiv Malhotra
Oct 22, 2013·Alimentary Pharmacology & Therapeutics·S S SamiK Ragunath
Nov 21, 2013·The New England Journal of Medicine·Robert P GiuglianoUNKNOWN ENGAGE AF-TIMI 48 Investigators
Dec 19, 2013·Circulation·Sumeet S ChughChristopher J L Murray
Mar 20, 2014·The American Journal of Gastroenterology·Christian S Jackson, Lauren B Gerson
Jun 6, 2014·Thrombosis and Haemostasis·M Franchini, P M Mannucci
Sep 19, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Renzo Y Loyaga-RendonSalpy V Pamboukian
Nov 5, 2014·Annals of Internal Medicine·Shadi KalantarianJeremy N Ruskin
Feb 11, 2015·The Journal of Clinical Endocrinology and Metabolism·Shlomo MelmedChristian Strasburger
Apr 4, 2015·Journal of the American College of Cardiology·Richard J KovacsKim A Williams
Apr 4, 2015·Gastroenterology Research and Practice·Julie Martin-Grace, Gianluca Tamagno
Dec 7, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Rajiv MalhotraDonald F Brophy
Mar 1, 2007·Expert Review of Endocrinology & Metabolism·Renato Cozzi, Roberto Attanasio

❮ Previous
Next ❯

Citations

Jul 25, 2019·Expert Review of Hematology·Monika KoziełGregory Y H Lip
Jan 8, 2020·Journal of Clinical Medicine·José María Mora-LujánAntoni Riera-Mestre
Oct 9, 2020·Stroke; a Journal of Cerebral Circulation·Eric ZhouShadi Yaghi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Related Papers

Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır
Ali OtoBanu Evranos
Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
Daniel CaldeiraFausto J Pinto
© 2022 Meta ULC. All rights reserved