Systemic overexpression of a C-terminal fragment of human amyloid beta-protein precursor causes accumulation of Alzheimer beta-amyloid fibrils in pancreas of transgenic mice

Gerontology
M ShojiS Hirai

Abstract

The deposition of amyloid beta-protein (A beta), derived from amyloid beta-protein precursor (beta APP), is a specific and early event in development of Alzheimer's disease. Transgenic mice carrying the carboxyl-terminus of beta APP gene linked to the cytomegalovirus enhancer/chicken beta-actin promoter sequence were studied. Deposition of amyloid fibrils, composing A beta, was observed in the transgenic pancreas, accompanied with cell degeneration. This result will provide a model to investigate the beta APP processing mechanism in vivo and a clue to generate possible A beta amyloidosis in animal brains.

Citations

Apr 14, 1999·Psychiatry and Clinical Neurosciences·K KosakaH Arai
Jul 4, 2001·Journal of Neurochemistry·J H BachS S Kim
Feb 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Claude NicolauRobert J Hopkins
Aug 21, 2019·Central Nervous System Agents in Medicinal Chemistry·Anurag K SinghGiriraj T Kulkarni

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