Systemic oxidative profile after tumor removal and the tumor microenvironment in melanoma patients

Cancer Letters
Sara Santos BernardesAlessandra L Cecchini

Abstract

This study highlights the systemic oxidative changes in patients submitted to primary cutaneous melanoma removal. Cutaneous melanoma is highly aggressive and its incidence is increasing worldwide. We evaluated systemic oxidative stress (OS) and 3-nitrotyrosine (3-NT) expression in melanoma tissue in relation to the Breslow thickness in patients under surveillance. Forty-three patients with cutaneous melanoma and 50 healthy volunteers were recruited. Patients were divided into two groups according to the tumor's Breslow thickness: T1/T2 (<2 mm) and T3/T4 (≥2 mm). Systemic OS and inflammatory mediators were evaluated in plasma, and the 3-NT expression was analyzed via immunohistochemistry. Compared with the controls, the patients had lower blood levels of reduced glutathione, higher malondialdehyde and thiol levels, and a higher total radical-trapping antioxidant parameter to uric acid ratio. The C-reactive protein and γ-glutamyl transpeptidase were increased only in the T3/T4 group. High levels of 3-NT were present only in T3/T4 patients. Our data suggested that a correlation exists between the Breslow thickness and a systemic pro-oxidant status, and that oxidative changes induced by the melanoma remain in the microenvironment p...Continue Reading

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Citations

Feb 14, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sara Santos BernardesAlessandra L Cecchini
May 5, 2017·Bioinformatics and Biology Insights·Nicholas LatchanaWilliam E Carson
Oct 24, 2018·Biological Chemistry·Elena ObradorJosé M Estrela
Sep 7, 2017·Melanoma Research·Fernando P de Souza NetoAlessandra L Cecchini
Jun 20, 2017·Integrative Cancer Therapies·Anita Thyagarajan, Ravi P Sahu
Apr 18, 2019·Oxidative Medicine and Cellular Longevity·Meghri KaterjiPenelope Duerksen-Hughes
Jul 29, 2020·Antioxidants·Anita ThyagarajanRavi P Sahu
Sep 10, 2020·Frontiers in Pharmacology·Nonhlakanipho F SangweniRabia Johnson
Oct 6, 2020·Journal of Biochemical and Molecular Toxicology·Rania SalahEl-Said El-Sherbini
Aug 13, 2021·Oxidative Medicine and Cellular Longevity·Salome Sadat SalehiManouchehr Nakhjavani

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