Systemic oxygen uptake during experimental closed-chest cardiopulmonary resuscitation using air or pure oxygen ventilation

Acta Anaesthesiologica Scandinavica
S RubertssonL Wiklund

Abstract

Although clinical cardiopulmonary resuscitation always includes ventilation with pure oxygen, this kind of ventilation has been reported to be associated with worse neurological outcome than ventilation with air in experimental cardiopulmonary resuscitation (CPR). The aim of the present investigation was to compare the systemic oxygen uptake during experimental closed-chest CPR including ventilation with pure oxygen or ambient air and, furthermore, to elucidate possible mechanisms of action in the regulation of pulmonary gas exchange. In 24 anesthetized piglets, 2 min of induced ventricular fibrillation and no ventilation was followed by 10 min of closed-chest CPR including i.v. administration of 0.5 mg adrenaline (at 8 min), and in one of the experimental groups alkaline buffer (at 5 min). The piglets were randomly divided into 3 groups: air ventilation during the entire CPR period with saline administration (n=8), air ventilation during the entire CPR period plus tris buffer mixture (n=8), and air ventilation for 3 min followed by 100% oxygen with saline administration (n= 8). In the group ventilated with air and treated with tris buffer mixture, cardiac output was significantly greater than in the group ventilated with pure ...Continue Reading

References

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Citations

May 18, 2016·The Indian Journal of Surgery·Tejaswini VallabhaK K Das
Apr 2, 2010·Journal of Occupational and Environmental Medicine·David S Zuby, Adrian K Lund

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