Systemic PPARγ deletion causes severe disturbance in fluid homeostasis in mice

Physiological Genomics
Li ZhouTianxin Yang

Abstract

The pharmacological action of peroxisome proliferator-activated receptor (PPAR)γ in promoting sodium and water retention is well documented as highlighted by the major side-effect of body weight gain and edema associated with thiazolidinedione use. However, a possible physiological role of PPARγ in regulation of fluid metabolism has not been reported by previous studies. Here we analyzed fluid metabolism in inducible whole-body PPARγ knockout mice. The null mice developed severe polydipsia and polyuria, reduced urine osmolality, and modest hyperphagia. The phenomenon persisted during 3 days of pair feeding and pair drinking, accompanied by progressive weight loss. After 24 h water deprivation, the null mice had a lower urine osmolality, a higher urine volume, a greater weight loss, and a greater rise in hematocrit than the floxed control. Urinary vasopressin (AVP) excretion was not different between the genotypes under basal condition or after WD. The response of urine osmolality to acute and chronic 1-desamino-8-D-arginine vasopressin treatment was attenuated in the null mice, but the total abundance or phosphorylation of aquaporin 2 (AQP2) in the kidney or AVP-induced cAMP production in inner medullary collecting duct suspens...Continue Reading

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Citations

Jul 15, 2016·International Journal of Molecular Sciences·Xiao-Yan ZhangYou-Fei Guan
Jul 29, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Britta Schulze BlasumBayram Edemir
Mar 12, 2020·International Journal of Nephrology·Yuhua MaJian Liu
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chun-Ling LiangJiu-Yao Zhou
Jul 5, 2018·Journal of Agricultural and Food Chemistry·Mulluru Somasundara Abignan Gurukar, Nandini D Chilkunda

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