PMID: 646474Apr 1, 1978

Systemic prophylaxis with doxycycline in surgery of the colon and rectum

Annals of Surgery
H Höjer, J Wetterfors

Abstract

A prospective double-blind study on the effects of doxycycline as a prophylactic antimicrobial in elective colonic surgery is presented. One hundred-eighteen patients were evaluated. Fifty-eight were treated and 60 were controls. Two hundred milligrams, doxycycline or placebo (two capsules) were given orally four to six hours prior to surgery and 100 mg or placebo (one capsule) for five days postoperatively. Doxycycline levels in serum and tissues were determined and related to the MICvalues of the contaminants of the operative field. A significantly lower incidence of abdominal wound sepsis, intra-abdominal complications, and septicemia was recorded in the doxycycline group compared to the control group, 12.1 and 45% respectively. The prophylactic effect was most pronounced in patients with a negative wound culture upon closure. Macroscopical peritoneal contamination was associated with less severe consequencies in the doxycycline group. Infections in the perineal field, 3/15 vs 8/17, appeared alone in the doxycycline group, whereas they were combined with abdominal sepsis in 6/8 among the controls. Treatment also reduced the incidence of repeat laparotomy due to septic complications, 0 vs 8. Thus systemic per and postoperativ...Continue Reading

References

Oct 1, 1976·Annals of Surgery·H H StoneE J Dawkins
May 1, 1977·The British Journal of Surgery·M R Keighley
Jan 1, 1976·American Journal of Surgery·H H LeVeenM Patel

Citations

Mar 1, 1993·World Journal of Surgery·W T Morris
Aug 1, 1984·Diseases of the Colon and Rectum·K A RietzG Lahnborg
May 1, 1983·Diseases of the Colon and Rectum·J PortnoyJ Mendelson
Oct 1, 1978·Diseases of the Colon and Rectum·C H Shatney, R C Lillehei
Mar 7, 2013·Surgical Infections·Dale W BratzlerSociety for Healthcare Epidemiology of America (SHEA)
Apr 1, 1980·Annals of Surgery·E P DellingerM Steer
May 15, 1984·The American Journal of Medicine·C E NordA Heimdahl
Jan 5, 2002·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·E P Dellinger
May 13, 2014·The Cochrane Database of Systematic Reviews·Richard L NelsonMarija Barbateskovic
May 1, 1987·Drug Intelligence & Clinical Pharmacy·L Danziger, E Hassan
Sep 1, 1984·Pharmacotherapy·T G Burnakis
Jan 1, 1981·Scandinavian Journal of Gastroenterology·D Raahave

Related Concepts

Bacterial Infections
Taenia Coli
Doxycycline Phosphate (1: 1)
Secondary Peritonitis
Postoperative Procedures
Postoperative Complications
Rectum
Surgical Wound Infection
Pyemia

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