Systemic, pulmonary and mesenteric perfusion and oxygenation effects of dopamine and epinephrine

American Journal of Respiratory and Critical Care Medicine
P Y CheungJ E Van Aerde


The response of the systemic, pulmonary, hepatic and portal circulations to infusion of dopamine and epinephrine was studied in newborn piglets 1 to 3 d of age. Anesthetized animals were instrumented to measure cardiac index (CI), hepatic arterial flow, and portal venous blood flow. Catheters were inserted for measurement of systemic arterial pressure (SAP), pulmonary arterial pressure (PAP), and for sampling of arterial, portal venous, and mixed venous oxygen saturations and plasma lactate levels. Systemic, pulmonary and mesenteric vascular resistance indices (SVRI, PVRI, MVRI), and systemic and mesenteric oxygen extraction were calculated. Dopamine and epinephrine were infused in doses of 2, 10, 32 microg/kg/min and 0.2, 1.0, 3.2 microg/kg/min respectively, given in random order. Significant increases in SAP, PAP, and CI were demonstrated with 32 microg/kg/min of dopamine and the two higher doses (1.0 and 3.2 microg/kg/min) of epinephrine. There were no significant changes in SVRI and PVRI with dopamine infusions. Epinephrine at 3.2 microg/kg/min significantly elevated SVRI and PVRI. The SAP/PAP ratio was decreased with 32 microg/kg/min of dopamine whereas epinephrine did not affect the ratio. Dopamine had no significant effe...Continue Reading


Oct 22, 1998·Critical Care Medicine·E SilvaJ L Vincent
Mar 13, 1999·Critical Care Medicine·J A Russell
Apr 10, 2002·Critical Care Medicine·Thomas W L ScheerenArtur Fournell
Jul 9, 2003·Critical Care Medicine·Lothar A SchwarteThomas W L Scheeren
Aug 6, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Christopher W MastropietroAshok P Sarnaik
Aug 17, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·M E CampbellD C Mayes
Oct 9, 2013·Seminars in Fetal & Neonatal Medicine·Samir Gupta, Steven M Donn
Oct 3, 1998·Intensive Care Medicine·A Uusaro
Mar 13, 2010·The American Journal of Emergency Medicine·Meng-Hua ChenFeng-Qing Song
Nov 3, 2007·Seminars in Fetal & Neonatal Medicine·Keith J Barrington
Dec 8, 1998·The Journal of Pediatrics·J F Padbury
Dec 8, 1998·The Journal of Pediatrics·I SeriJ S Gerdes
May 21, 2015·Indian Journal of Pediatrics·B Vishnu Bhat, Nishad Plakkal
Aug 19, 2017·Pediatric Research·Regan E GiesingerPatrick J McNamara
Sep 21, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·A S SikarwarS Dakshinamurti
Oct 3, 2006·Current Opinion in Anaesthesiology·J Boldt
Apr 16, 2016·Critical Care Medicine·Katherine N SlainAlexandre T Rotta
Jun 21, 2018·Paediatric Drugs·Roberto AntonucciLaura Cuzzolin
Feb 20, 2004·The Cochrane Database of Systematic Reviews·M Paradisis, D A Osborn
Jul 13, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S JaillardL Storme

Related Concepts

Diastolic Blood Pressure
Cardiac Output
Cardiotonic Agents
Dose-Response Relationship, Drug
Hepatic Artery
Liver Circulation

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.