Systemic reactive angioendotheliomatosis-like syndrome in a steer presumed to be persistently infected with bovine viral diarrhea virus

Veterinary Pathology
M A Breshears, B J Johnson

Abstract

Unusual proliferative intravascular lesions were seen in multiple organs of a 2-year-old Corriente steer presumed to be persistently infected with bovine viral diarrhea virus (BVDV), based on widespread immunohistochemical detection of BVDV antigen. Proliferations of spindle cells, which were immunohistochemically positive for von Willebrand factor-related antigen, partially-to-completely occluded vessel lumens and were supported by cells that were immunohistochemically positive for smooth muscle actin. Distribution and character of the intraluminal proliferations are strikingly similar to those described in feline systemic reactive angioendotheliomatosis, a rare entity of unknown cause. The presence of occasional intravascular thrombi suggests that the proliferative vasculopathy was associated with an underlying thrombotic process with immunohistochemical similarities to thrombotic thrombocytopenic purpura of humans. Death of the steer was due to hemorrhage from a castration wound, which may indicate thrombocytopenia or platelet dysfunction. The role of persistent BVDV infection in the formation of the intravascular lesions is unknown.

References

Jan 1, 1989·Journal of Veterinary Internal Medicine·W C RebhunL F Karcher
Oct 1, 1988·Journal of Cutaneous Pathology·M R Wick, A Rocamora
Sep 1, 1985·Veterinary Pathology·T L RothwellJ S Davies
Jul 1, 1993·Journal of Comparative Pathology·U Straumann KunzG Lott-Stolz
Feb 1, 1996·The American Journal of Dermatopathology·R LazovaG Scott
Feb 1, 1997·The Veterinary Record·K A DunnA S Blunden
Oct 23, 1997·The American Journal of Surgical Pathology·B T LinH Battifora
Aug 29, 2000·Journal of Clinical Pathology·S L Allford, S J Machin
Oct 6, 2000·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·B L NjaaD M Haines
Jan 18, 2003·Journal of Comparative Pathology·L CarrascoP Bollen
Nov 9, 2005·American Journal of Veterinary Research·Paul H WalzKenny V Brock
Apr 22, 2006·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·R PiccininiA Zecconi
Jul 19, 2006·Veterinary Pathology·K A MarateaG W Stevenson

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Citations

Mar 28, 2012·Medical Microbiology and Immunology·Christiane BeerlageEdward B Breitschwerdt
Aug 1, 2015·International Journal of Dermatology·Ghada A Bin SaifOmar P Sangueza
Dec 12, 2020·Veterinary Pathology·Jacqueline MarrBrian A Summers

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