Systemic release of soluble TNF receptors after high-dose TNF in isolated limb perfusion

Cytokine
J GerainF Lejeune

Abstract

Isolated limb perfusion (ILP) with high dose tumour necrosis factor (TNF), interferon gamma and melphalan (TIM) is an efficient treatment for patients with regionally advanced melanoma and sarcoma. In 44 patients, we determined the kinetics of soluble TNF receptors (sTNF-RI and RII) plasma concentrations, and correlated them with systemic TNF and interleukin 6 (IL-6) levels and shock. Seven patients treated conventionally by ILP without cytokine served as controls. Elevated levels of both sTNF-Rs were observed within 30 min after beginning of the TIM-ILP. A first peak of sTNF-Rs levels was observed 3 h after ILP and was followed by a rapid decrease reaching a nadir at 12-14 h post ILP. This first peak was followed by a second, long-lasting elevation of both sTNF-Rs levels persisting for 4 to 5 days after TIM-ILP. Patients treated by ILP without TNF/interferon gamma (IFN-gamma) had no detectable increase in either sTNF-Rs or in circulating TNF, demonstrating that the release of TNF-Rs was dependent upon the administration of TNF/IFN-gamma. High plasma levels of TNF and IL-6 were observed in patients that had more than 5% leakage during the TIM-ILP, but no significant correlation between TNF levels and the peak values of both sTN...Continue Reading

Citations

Oct 31, 1998·Current Opinion in Immunology·F J LejeuneD Liénard
Nov 16, 2010·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Florian GrabellusGeorg Taeger
Apr 15, 2006·International Journal of Cancer. Journal International Du Cancer·Remco van HorssenAlexander M M Eggermont
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P DriP Patriarca
Jul 11, 2006·Journal of Applied Physiology·Ginette S HoareMagdi H Yacoub
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M GotoR E Kimura

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